Asian Journal of Research in Chemistry

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Synthesis, Characterisation, DNA Binding/Cleavage, Anticancer and Antimicrobial Activity of Ternary Copper(II) Complexes


Affiliations
1 Department of Chemistry, Thiruvalluvar University, Vellore – 632 115, Tamilnadu, India
2 Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam – 638 401, Tamilnadu, India
     

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Ternary copper(II) complexes [Cu(L-Ser)(HB)(U)](ClO4) (1 and 2) where L-Ser = L-Serine, U = Urea, HB is a N,N-donor heterocyclic bases, viz. 1,10-phenanthroline (phen) (1), 2,2'- bipyridine (bpy) (2), are synthesized, characterized, and their DNA binding, cleavage and antimicrobial activities are studied. The one-electron paramagnetic complexes display a d-d band near 600 nm in water. Binding interactions of the complexes with calf thymus (CT) DNA have been investigated by absorption, emission, viscosity, and cyclic voltammetry studies. The complexes cleave the supercoiled DNA (pBR 322) to its nicked circular form in the presence of gallic acid at appropriate complexes concentration. The phen complex (1) displays significant binding propensity to the CT DNA. The bpy complex (2) does not show any significant binding to the DNA and hence poor cleavage efficiency.

Keywords

1,10-Phenanthroline, 2,2’-Bipyridine, Copper, DNA Binding, MTT Assay.
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  • Synthesis, Characterisation, DNA Binding/Cleavage, Anticancer and Antimicrobial Activity of Ternary Copper(II) Complexes

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Authors

S. Dhakshanamoorthy
Department of Chemistry, Thiruvalluvar University, Vellore – 632 115, Tamilnadu, India
M. Murali Krishnan
Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam – 638 401, Tamilnadu, India
M. N. Arumugham
Department of Chemistry, Thiruvalluvar University, Vellore – 632 115, Tamilnadu, India

Abstract


Ternary copper(II) complexes [Cu(L-Ser)(HB)(U)](ClO4) (1 and 2) where L-Ser = L-Serine, U = Urea, HB is a N,N-donor heterocyclic bases, viz. 1,10-phenanthroline (phen) (1), 2,2'- bipyridine (bpy) (2), are synthesized, characterized, and their DNA binding, cleavage and antimicrobial activities are studied. The one-electron paramagnetic complexes display a d-d band near 600 nm in water. Binding interactions of the complexes with calf thymus (CT) DNA have been investigated by absorption, emission, viscosity, and cyclic voltammetry studies. The complexes cleave the supercoiled DNA (pBR 322) to its nicked circular form in the presence of gallic acid at appropriate complexes concentration. The phen complex (1) displays significant binding propensity to the CT DNA. The bpy complex (2) does not show any significant binding to the DNA and hence poor cleavage efficiency.

Keywords


1,10-Phenanthroline, 2,2’-Bipyridine, Copper, DNA Binding, MTT Assay.