Asian Journal of Research in Chemistry

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A Non-Cytotoxic Pseudo Peptide KL1 with Potent Antioxidant Activity


Affiliations
1 Department of Chemistry, Yuvaraja's College, University of Mysore, Mysore - 570 005, India
2 Adichunchanagiri Institute for Molecular Medicine, B.G. Nagara, Mandya-571 448, India
3 Department of Chemistry, PES College of Engineering, Mandya-571401, India
     

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By incorporating a reduced amide bond φ [CH2NH] into α helical antibacterial peptide, we made an attempt to synthesize an antioxidant pseudo peptide. When the pKa value of reduced amide bond is between 6.5 to7.5, it is protonated depending on the pH. We investigated the antioxidant activity by hydroxyl radical scavenging assay and DPPH radical scavenging assay, the results showed that, the antioxidant activity of KL1 pseudo peptide (51%, 56%) were promising when compared to standard antioxidants like BHA(68%, 78%) and BHT (65%, 81%) respectively. The cyto-toxicity studies of the pseudo peptide showed that the peptide is non-toxic to cells.

Keywords

Pseudopeptide, Reduced Amide Bond Selectivity, Antioxidant, DPPH Radical, Superoxide Radical.
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  • A Non-Cytotoxic Pseudo Peptide KL1 with Potent Antioxidant Activity

Abstract Views: 265  |  PDF Views: 1

Authors

M. M. Gangadhara
Department of Chemistry, Yuvaraja's College, University of Mysore, Mysore - 570 005, India
R. Dinesha
Adichunchanagiri Institute for Molecular Medicine, B.G. Nagara, Mandya-571 448, India
Satish Kumar Murari
Department of Chemistry, PES College of Engineering, Mandya-571401, India

Abstract


By incorporating a reduced amide bond φ [CH2NH] into α helical antibacterial peptide, we made an attempt to synthesize an antioxidant pseudo peptide. When the pKa value of reduced amide bond is between 6.5 to7.5, it is protonated depending on the pH. We investigated the antioxidant activity by hydroxyl radical scavenging assay and DPPH radical scavenging assay, the results showed that, the antioxidant activity of KL1 pseudo peptide (51%, 56%) were promising when compared to standard antioxidants like BHA(68%, 78%) and BHT (65%, 81%) respectively. The cyto-toxicity studies of the pseudo peptide showed that the peptide is non-toxic to cells.

Keywords


Pseudopeptide, Reduced Amide Bond Selectivity, Antioxidant, DPPH Radical, Superoxide Radical.