Comparison of Anti-Hyperlipidemic Activity in Ashwagandharishta Prepared by Traditional and Modern Methods

The present study was carried out to compare the lipid peroxidation activity and related hypolipidaemic activity in Ashwagandhrishta-T and Ashwagandhrishta-M prepared by traditional and modern methods with standard Atorvastatin. Hypolipidaemic activity was evaluated on cholesterol fed rats. The antioxidant activity of Ashwagandharishta-T and Ashwagandharishta-M was increased in a concentration dependent manner. Ashwagandharishta-T and Ashwagandharishta-M inhibited the ferrous sulphate induced lipid per-oxidation in a dose dependent manner and showed inhibitory concentration (IC₅₀) value 181.88 and 191.05 μl/ml, respectively. In hypolipidemic activity Ashwagandharishta-T and Ashwagandharishta-M at the dose of 2.0 ml/kg body weight orally significantly reduced serum cholesterol (47% and 46%), serum LDL (66% and 65%), and serum triglycerides (35% and 34%). The increase in serum HDL was 19% when compared to control with both the Ashwagandharishta T and M and reduction in atherogenic index was found 1.25 and 1.29 in Ashwagandharishta-T and Ashwagandharishta-M treated groups respectively, which strongly supports anti-atherosclerotic property of Ashwagandharishta.