Asian Journal of Research in Chemistry

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Synthesis and Biological Evaluation of Indole Fused Triazine Derivatives


Affiliations
1 Department of Pharmacy, Saroj Institute of Technology and Management, Sultanpur Road, Lucknow-226002, U.P., India
2 Department of Microbiology, Institute of Medical Science, Banaras Hindu University, Varanasi, U.P., India
     

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A series of indole fused triazine derivatives have been synthesized and characterized by elemental and spectral analysis, further the compounds have been screened for antimicrobial activity against ten strains of Gram (+) and Gram (-) bacteria. Compound 5a was found to be most active in the series against E. faecalis ATCC29212 with MIC 12.5 μg/mL. From the antimicrobial screening result, it was observed that the newly synthesized compounds 5a, 5i and 5j showed good antimicrobial activity compared with standard sulphamethoxazole.

Keywords

Triazine, Antibacterial Activity, MIC Value, Indole Nucleus.
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  • Synthesis and Biological Evaluation of Indole Fused Triazine Derivatives

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Authors

Surendra Nath Pandeya
Department of Pharmacy, Saroj Institute of Technology and Management, Sultanpur Road, Lucknow-226002, U.P., India
Rajeev Kumar
Department of Pharmacy, Saroj Institute of Technology and Management, Sultanpur Road, Lucknow-226002, U.P., India
Gopal Nath
Department of Microbiology, Institute of Medical Science, Banaras Hindu University, Varanasi, U.P., India
Ashish Kumar Pathak
Department of Pharmacy, Saroj Institute of Technology and Management, Sultanpur Road, Lucknow-226002, U.P., India

Abstract


A series of indole fused triazine derivatives have been synthesized and characterized by elemental and spectral analysis, further the compounds have been screened for antimicrobial activity against ten strains of Gram (+) and Gram (-) bacteria. Compound 5a was found to be most active in the series against E. faecalis ATCC29212 with MIC 12.5 μg/mL. From the antimicrobial screening result, it was observed that the newly synthesized compounds 5a, 5i and 5j showed good antimicrobial activity compared with standard sulphamethoxazole.

Keywords


Triazine, Antibacterial Activity, MIC Value, Indole Nucleus.