Asian Journal of Research in Chemistry

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Estimation of Mefenamic Acid in its Bulk and Tablet Formulation by RP-HPLC Method


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1 Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli (M.S.), India
     

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Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities. A simple, rapid and specific method for analysis of mefenamic acid in bulk and tablet dosage form by a sensitive high-performance liquid chromatography is described. The mefenamic acid peak was developed on a C8 column by a mobile phase of acetonitrile: water. Mefenamic acid and internal standard (IS) diclofenac sodium were eluted at 3.133 and 2.750 min, respectively. The limit of quantitation and limit of detection of mefenamic acid in tablet was 0.9508 μg/ml and 0.3137 μg/ml at 288 nm. The method was linear over the range of 10-90 μg/ml with r2 of 0.99965.

Keywords

Mefenamic Acid, High Performance Liquid Chromatography, Limit of Quantification, Limit of Detection.
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  • Estimation of Mefenamic Acid in its Bulk and Tablet Formulation by RP-HPLC Method

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Authors

M. S. Teli
Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli (M.S.), India
S. S. Sawant
Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli (M.S.), India
S. R. Kumbhoje
Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli (M.S.), India
A. S. Ravetkar
Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli (M.S.), India
M. S. Kondawar
Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli (M.S.), India

Abstract


Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activities. A simple, rapid and specific method for analysis of mefenamic acid in bulk and tablet dosage form by a sensitive high-performance liquid chromatography is described. The mefenamic acid peak was developed on a C8 column by a mobile phase of acetonitrile: water. Mefenamic acid and internal standard (IS) diclofenac sodium were eluted at 3.133 and 2.750 min, respectively. The limit of quantitation and limit of detection of mefenamic acid in tablet was 0.9508 μg/ml and 0.3137 μg/ml at 288 nm. The method was linear over the range of 10-90 μg/ml with r2 of 0.99965.

Keywords


Mefenamic Acid, High Performance Liquid Chromatography, Limit of Quantification, Limit of Detection.