Asian Journal of Research in Chemistry

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New UV-Visible Spectrophotometric Methods for the Determination of Levetiracetam in Bulk and Pharmaceutical Formulation


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1 Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India
     

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A three simple, sensitive and reproducible UV-Visible spectrophotometric methods (Method A to Method C) are developed for the determination of Levetiracetam (LEVT) in pure and dosage forms. Method A is based on the formation of colored species on treatment of Levetiracetam (LEVT) with 3-Methyl-2-benzo thiazolinone hydrazone (MBTH) and Cerric Ammonium Sulphate (CAS). Method B is based on the formation of colored species on treatment of Levetiracetam (LEVT) with Fecl3 and 1,10 PTL. Method C represents UV Spectrophotometric determination of Levetiracetam and its dosage forms in Methanol at 210 nm.
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  • New UV-Visible Spectrophotometric Methods for the Determination of Levetiracetam in Bulk and Pharmaceutical Formulation

Abstract Views: 139  |  PDF Views: 0

Authors

S. Ganapathy
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India
G. V. H. Raju
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India
D. G. Sankar
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India
Pettla Y. Naidu
Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India

Abstract


A three simple, sensitive and reproducible UV-Visible spectrophotometric methods (Method A to Method C) are developed for the determination of Levetiracetam (LEVT) in pure and dosage forms. Method A is based on the formation of colored species on treatment of Levetiracetam (LEVT) with 3-Methyl-2-benzo thiazolinone hydrazone (MBTH) and Cerric Ammonium Sulphate (CAS). Method B is based on the formation of colored species on treatment of Levetiracetam (LEVT) with Fecl3 and 1,10 PTL. Method C represents UV Spectrophotometric determination of Levetiracetam and its dosage forms in Methanol at 210 nm.