Synthesis and Biological Activity of 5-Substituted and 5, 6-Disubstituted-2-(N, N-Dialkyl Thiocarbamido) Benzimidazoles

Heterocyclic compounds such as 5-substituted and 5,6-disubstituted-2-(N, N-dialkyl Thiocarbamido) benzimidazoles were synthesized by condensation of 5-substituted and 5,6-disubstituted-2-mercapto benzimidazoles with N, N-dialkyl carbamoyl chlorides and triethyl amine in dry 1,4-dioxane. Synthesized compounds were further screened for their biological activity and found to have good to moderate antibacterial and antifungal activity. The structures of compounds have been established on basis of their elemental analysis and spectral data (IR and NMR).