Asian Journal of Research in Chemistry

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Synthesis and Antimicrobial Activity of 5-Substituted-2-(1-H-Benzimidazole) Sulfonamides


Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, India
     

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Heterocyclic compounds such as 5-substituted-2-(1-H-benzimidazole) sulfonamides were synthesized by condensation of 5-substituted-2-(1-H-benzimidazole)-sulfonyl chloride and 2-aminoheterocycles with triethyl amine in dry acetone. The synthesized compounds were checked for their antimicrobial potency by screening them against two bacterial strains as well as one fungal strain. The structures of compounds have been established on the basis of their elemental analysis and spectral data.

Keywords

Sulphonamides, 2-Mercapto Benzimidazole, Antifungal, Antibacterial.
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  • Synthesis and Antimicrobial Activity of 5-Substituted-2-(1-H-Benzimidazole) Sulfonamides

Abstract Views: 200  |  PDF Views: 0

Authors

Y. S. Rane
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, India
R. R. Varma
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, India
L. S. Patil
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, India
S. V. Athlekar
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, India
A. S. Chowdhary
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, India
A. S. Bobade
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-12, India

Abstract


Heterocyclic compounds such as 5-substituted-2-(1-H-benzimidazole) sulfonamides were synthesized by condensation of 5-substituted-2-(1-H-benzimidazole)-sulfonyl chloride and 2-aminoheterocycles with triethyl amine in dry acetone. The synthesized compounds were checked for their antimicrobial potency by screening them against two bacterial strains as well as one fungal strain. The structures of compounds have been established on the basis of their elemental analysis and spectral data.

Keywords


Sulphonamides, 2-Mercapto Benzimidazole, Antifungal, Antibacterial.