Asian Journal of Research in Chemistry

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Synthesis and Antimicrobial Activity of Some 3-Substituted-4H-1, 2, 4-Triazole Derivatives


Affiliations
1 B N Girls’ College of Pharmacy, Udaipur (Raj.), India
2 Jodhpur Pharmacy College, Jodhpur (Raj.), India
3 Rayat Bahara College of Pharmacy, Ropad Campus, Chandigarh, India
4 B N College of Pharmacy, Udaipur (Raj.), India
     

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Five new 3-substituted -4H-1, 2, 4-triazoles derivates 4 (a-e) were synthesized by treatment of 4-alkyl diazo substituted 4H-1, 2,4-triazoles-3-thiole with different aliphatic and aromatic amines to give the titled compounds. All the synthesized derivatives were characterized by spectral (UV, IR, 1H-NMR, MS) and elemental analysis. The in vitro antimicrobial activity of all the derivatives were evaluated against the pathogens, S. aureus, B. subtilis, P. aeruginosa, E. coli, A. niger and C. albicans. Some derivatives were found to possess very promising antimicrobial activity.

Keywords

4H-1, 2, 4-Triazole, Antimicrobial.
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  • Synthesis and Antimicrobial Activity of Some 3-Substituted-4H-1, 2, 4-Triazole Derivatives

Abstract Views: 216  |  PDF Views: 0

Authors

P. K. Goyal
B N Girls’ College of Pharmacy, Udaipur (Raj.), India
A. Bhandari
Jodhpur Pharmacy College, Jodhpur (Raj.), India
A. C. Rana
Rayat Bahara College of Pharmacy, Ropad Campus, Chandigarh, India
D. S. Bele
B N College of Pharmacy, Udaipur (Raj.), India

Abstract


Five new 3-substituted -4H-1, 2, 4-triazoles derivates 4 (a-e) were synthesized by treatment of 4-alkyl diazo substituted 4H-1, 2,4-triazoles-3-thiole with different aliphatic and aromatic amines to give the titled compounds. All the synthesized derivatives were characterized by spectral (UV, IR, 1H-NMR, MS) and elemental analysis. The in vitro antimicrobial activity of all the derivatives were evaluated against the pathogens, S. aureus, B. subtilis, P. aeruginosa, E. coli, A. niger and C. albicans. Some derivatives were found to possess very promising antimicrobial activity.

Keywords


4H-1, 2, 4-Triazole, Antimicrobial.