Redox Behavior and DNA Cleavage Studies of Copper (II) Schiff Base Complex Derived from 2-Aminobenzaldehyde

The tetradentate Schiff base ligand was prepared by condensation of 2-aminobenzaldehyde with o-phenylenediamine. The synthesized complex has been studied by using cyclic voltammetry and DNA cleavage studies. The resulting voltammogram consists of a single quasi-reversible one electron transfer attribute to couple [Cu(II)L]/[Cu(I)L]. Trends in cathodic peak potential (Epc) values are observed which can be correlated with electron effects of Schiff base ligand, changes with basis of liquid groups are determinant for electrochemical trends. The interaction of Cu(II) complex with Calf Thymus DNA has been studied by using absorption, viscosity and cyclic voltammetry. Cyclic voltammetry studies reveal that the complex prefer to bind to DNA in Cu(II) rather than (I) oxidation state.