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Synthesis and Biological Activities of Some Benzothiazole Derivatives
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Substituted benzothiazoles have received considerable attention during last two decades as they are endowed with variety of biological activities and have wide range of therapeutic properties. A Literature survey indicates that benzothiazole derivatives possess different pharmacological and biological activities; which of most potent activity are anti-inflammatory and anti-bacterial activity. The starting product is 6-substituted-1, 3-benzothiazol-2-amine was prepared from 4-substituted anilines and potassium thiocyanate in one step. Substituted Benzothiazolyl-2-amines were reacted with chloroacetyl chloride to yield 2-chloro acetyl amino-6-substitued benzothiazoles, which were reacted with 2-mercaptobenzothiazole and 2-hydrazinobenzthiazole gave 2-(1,3-benzothiazol-2-yl thio)-N-(6-substitued-1,3-benzothiazol-2-yl) acetamides and 2-[2-(1,3-benzothiazol-2-yl)hydrazino]-N-(6-methyl-1,3-benzothiazol-2-yl) acetamides respectively. The synthesized compounds were characterized by elemental analysis and spectral data.
Keywords
Benzothiazoles, Antibacterial, Antifungal.
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