Synthesis of Some 1-[Bis-N, N-(2-Chloroethyl) Aminoacetyl]-3, 5-Disubstituted-1, 2-Pyrazolines as Possible Alkylating Anticancer Agents

A series of 1-[Bis-N, N-(2-Chloroethyl) aminoacetyl]-3,5-disubstituted-1,2 pyrazolines have been synthesized by the treatment of 1-[Bis-N, N-(2-hydroxyethyl) aminoacetyl]-3,5-disubstituted-1,2-pyrazolines with Phosphorous oxychloride, the starting compound pyrazoline was synthesized from various aldehydes and acetophenones. The synthesized compounds have been characterized by their analytical, IR, 1H-NMR and mass spectral data. The titled compounds were investigated for their possible anticancer activities by in vitro and in vivo methods. These compounds were found to exhibit a moderate anticancer activity when compared to cyclophosphamide employed as a reference drug for comparison.