Analgesic and Anti-Inflammatory Activity of Some 2-Iodo-N'-[(1E)-Substituted Phenylmethylidene] Benzohydrazide Analogues

In the present study, eight compounds of phenylmethylidene benzohydrazide derivatives of o-iodo benzoic acid were synthesized by reacting 2-iodo benzohydrazide (1) with appropriately substituted aromatic aldehyde in glacial acetic acid yielded corresponding 2-Iodo-N'-[(1E)-Substituted Phenylmethylidene] Benzohydrazides (2). Structures of all the compounds (2) were established on the basis of elemental analysis and spectral data. These compounds were screened for analgesic activity by using Writhing test and Tail immersion method while Anti-inflammatory activity by rat paw edema method. Some of derivatives amongst them were showed significant activity against relative standards used for respective animal model.