New Emerging Targets for Obesity

The increasing prevalence of obesity worldwide has prompted the world health organization (WHO) to classify it as a global epidemic. A round the global, more than a half a billion people are overweight and the chronic disease of obesity represents a major threat to health care system in developed and developing countries. Energy homeostasis is accomplished through a highly integrated and reductant neurohumoral system. Adrenergic and seretonergic agents enjoyed before is now disfavored due to abuce and lack of exact receptor subtype profile respectively.ß3-adrenergic receptor agonist acting, as thermogenic agents are new approach and its value will become apparent once data are available from relevant clinical evaluation some drug from this class are under clinical trials. Transgenic technology has provided new opportunities to modify the complex body weight regulation system and to asses the relative importance of the individual components. Certain peptides have been used successfully as antiobesity agents. They reduced gastrointestinal absorption and affect feeding behavior. Since obesity result from genetic predispotion, combined with the proactive environment situation, we discuss new potential targets for generation of drugs that may help people in gaining control over appetite as well as increase total energy expenditure and fat oxidation.