Asian Journal of Research in Chemistry

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Synthesis of Some Novel Coumarino Benzimidazoles Derivatives for Anti-Inflammatory Screening


Affiliations
1 East Point College of Pharmacy, Bidarahalli, Virgonagar Post, Bangalore-560049, India
2 Krupanidhi College of Pharmacy, Chikkabelandur, Carmelaram Post, Varthur Hobli, Bangalore-560035, India
3 Badar Al Samaa Hospital, P.O Box-516, PC-321, Barka, Oman
     

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A series of eight coumarino benzimidazoles have been synthesized from 4-fluro-3-nitrobenzoic acid with the help of a supporting polymer PEG5000 and with suitable reagents. These compounds have then been subjected to preliminary anti-inflammatory screening using formaline induce rat paw oedema model. All the synthesized compounds have activity comparable to indomethacin (20 mg/kg) by intraperitonial route.

Keywords

Coumarino Benzimidazoles, PEG5000, Anti-Inflammatory Activity.
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  • Synthesis of Some Novel Coumarino Benzimidazoles Derivatives for Anti-Inflammatory Screening

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Authors

Jacob Jincy
East Point College of Pharmacy, Bidarahalli, Virgonagar Post, Bangalore-560049, India
Dey Tathagata
East Point College of Pharmacy, Bidarahalli, Virgonagar Post, Bangalore-560049, India
Ghate Manjunath
Krupanidhi College of Pharmacy, Chikkabelandur, Carmelaram Post, Varthur Hobli, Bangalore-560035, India
Baby Shaji
Badar Al Samaa Hospital, P.O Box-516, PC-321, Barka, Oman

Abstract


A series of eight coumarino benzimidazoles have been synthesized from 4-fluro-3-nitrobenzoic acid with the help of a supporting polymer PEG5000 and with suitable reagents. These compounds have then been subjected to preliminary anti-inflammatory screening using formaline induce rat paw oedema model. All the synthesized compounds have activity comparable to indomethacin (20 mg/kg) by intraperitonial route.

Keywords


Coumarino Benzimidazoles, PEG5000, Anti-Inflammatory Activity.