Asian Journal of Research in Chemistry

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Synthesis and Pharmacological Evaluation of Atypical Antipsychotic Activity of New Coumarinoacetamides


Affiliations
1 Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-7861004, Assam, India
2 Poona College of Pharmacy, Bharti Vidyapeeth University, Pune-411038, India
     

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A new series of coumarinaoacetamides (3a-h) have been synthesized by refluxing various chloroacetamides (2a-h) with 7-hydroxy-4-methyl chromen-2-one (1) in acetonitrile and anhydrous K2CO3. The chloroacetamides have been prepared from the chloroacetyl chloride with various substituted amines. The synthesized compounds have been characterized with the help of spectral and analytical data. The title compounds were screened for their antipsychotics activity in terms of their ability to inhibit apomorphine induced climbling behaviour in albino Swiss mice. All the compounds showed significant activity.

Keywords

Schizophrenia, Atypical Antipsychotics, Coumarinoacetamides.
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  • Synthesis and Pharmacological Evaluation of Atypical Antipsychotic Activity of New Coumarinoacetamides

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Authors

Sanjib Das
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-7861004, Assam, India
R. C. Das
Poona College of Pharmacy, Bharti Vidyapeeth University, Pune-411038, India
S. H. Bhosale
Poona College of Pharmacy, Bharti Vidyapeeth University, Pune-411038, India
Ashish A. Gawai
Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-7861004, Assam, India

Abstract


A new series of coumarinaoacetamides (3a-h) have been synthesized by refluxing various chloroacetamides (2a-h) with 7-hydroxy-4-methyl chromen-2-one (1) in acetonitrile and anhydrous K2CO3. The chloroacetamides have been prepared from the chloroacetyl chloride with various substituted amines. The synthesized compounds have been characterized with the help of spectral and analytical data. The title compounds were screened for their antipsychotics activity in terms of their ability to inhibit apomorphine induced climbling behaviour in albino Swiss mice. All the compounds showed significant activity.

Keywords


Schizophrenia, Atypical Antipsychotics, Coumarinoacetamides.