Asian Journal of Research in Chemistry

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Synthesis and Anti-Inflammatory Activity of Some New 2-Amino-4, 6, Diaryl Pyrimidines


Affiliations
1 Dept. of Pharma. Chemistry, Sree Siddaganga College of Pharmacy, B.H. Road, Tumkur-572102, Karnataka, India
     

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Some new pyrimidine derivatives were synthesized by reacting chalcones of 2-acetyl thiophene with guanidine hydrochloride in the presence of alcohol. The synthesized compounds were identified by spectral data and screened for anti-inflammatory activity. Some of these compounds showed moderate to considerable anti-inflammatory activity.

Keywords

Synthesis, Pyrimidines, Anti-Inflammatory Activity.
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  • Synthesis and Anti-Inflammatory Activity of Some New 2-Amino-4, 6, Diaryl Pyrimidines

Abstract Views: 207  |  PDF Views: 0

Authors

B. Ramesh
Dept. of Pharma. Chemistry, Sree Siddaganga College of Pharmacy, B.H. Road, Tumkur-572102, Karnataka, India
R. N. Umashankar
Dept. of Pharma. Chemistry, Sree Siddaganga College of Pharmacy, B.H. Road, Tumkur-572102, Karnataka, India
S. Babitha
Dept. of Pharma. Chemistry, Sree Siddaganga College of Pharmacy, B.H. Road, Tumkur-572102, Karnataka, India

Abstract


Some new pyrimidine derivatives were synthesized by reacting chalcones of 2-acetyl thiophene with guanidine hydrochloride in the presence of alcohol. The synthesized compounds were identified by spectral data and screened for anti-inflammatory activity. Some of these compounds showed moderate to considerable anti-inflammatory activity.

Keywords


Synthesis, Pyrimidines, Anti-Inflammatory Activity.