Facile and Efficient Oxidation of Sulfides to Sulfoxides Using Oxone® and its Biological Evaluation

A “green” highly sensitive oxidation of organic sulfides, N-substituted-β-(4-phenyl-2-thiazolyl) thio-alkyl/aryl acetamides (I) to the corresponding sulfoxides (II) was developed employing solid-state condition by using Oxone^®. The synthesized compounds were confirmed by using elemental analysis and spectral data. These synthesized compounds were tested for their antibacterial and antifungal activities. None of them were found to possess any promising activity. This oxidation system is found clean, safe and operationally simple, environmental friendly and for these reasons meets the needs of contemporary “green chemistry” and is suitable for practical synthesis.