Synthesis and Biological Screening of Some Novel 4-Thiazolidinone Derivatives

A new series of substituted 4-thiazolidionones were synthesized by cyclization of Schiff’s bases with thiooglycollic acid. The substituted schiff’s bases were synthesized starting from substituted benzoic acid with thionyl chloride in 3 steps. The structures of the synthesized compounds have been established on the basis of physical and spectral data and are screened for anticonvulsant, antibacterial and anti hyperglycemic activities; some of them exhibited significant activity.