UV Spectrophotometric Method Development for the Determination of Domperidone in Tablet Formulation

A simple, accurate, precise and reproducible method for the estimation of domperidone (DOM) in tablet dosage form was developed utilizing concept of UV spectrophotometry. Methanol was used as the solvent for domperidone. The UV spectrum of domperidone in methanol showed λmax at 287.5 nm and Beer-Lambert law was obeyed in the concentration range of 6-36 μg/ml. Wavelength selected for estimation of domperidone was 287.5 nm. The result of analysis has been validated statistically. The recovery studies range from 99.5 to 100.1% confirmed the accuracy of the proposed methods.