Asian Journal of Research in Chemistry

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Synthesis and Anti-Bacterial Study of 6, 8-Disubstituted-3-(4-(4-Substituted Phenyl) Thiazol-2-Yl)-3,4-Dihydro-2H-Benzo [E][1,3] Oxazine


Affiliations
1 Department of Pharmaceutical and Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Near Arvind Baug, Mehsana-384001, Gujarat, India
     

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6, 8-Disubstituted-3-(4-(4-Substituted Phenyl)Thiazol-2-yl)-3,4-Dihydro-2H-Benzo [E][1,3] Oxazine have been prepared from 2-amino 4-substituted Phenyl thiazole react with substituted salicyladehyde results in 2,4-disubstituted-6-((4-(4- substituted phenyl) thiazol-2-ylimino) methyl) phenol. Then reacted with NaBH4, it give 2,4-disubstituted-6-((4-(4-substituted phenyl) thiazol-2-ylamino) methyl) phenol. Which is reacted with fomalin in chloroform yields 6, 8-Disubstituted-3-(4-(4-Substituted Phenyl) Thiazol-2-yl)-3,4-Dihydro-2H-Benzo [E][1,3] Oxazine. All the title compounds characterised on the basis of their MASS, 1H NMR spectroscopic data analysis.

Keywords

Synthesis, Thiazole, Salicyladehyde, Anti-Bacterial Activity.
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  • Synthesis and Anti-Bacterial Study of 6, 8-Disubstituted-3-(4-(4-Substituted Phenyl) Thiazol-2-Yl)-3,4-Dihydro-2H-Benzo [E][1,3] Oxazine

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Authors

Kiran J. Suthar
Department of Pharmaceutical and Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Near Arvind Baug, Mehsana-384001, Gujarat, India
Harsha U. Patel
Department of Pharmaceutical and Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Near Arvind Baug, Mehsana-384001, Gujarat, India
Chhaganbhai N. Patel
Department of Pharmaceutical and Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Near Arvind Baug, Mehsana-384001, Gujarat, India
Vimal Patel
Department of Pharmaceutical and Medicinal Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Near Arvind Baug, Mehsana-384001, Gujarat, India

Abstract


6, 8-Disubstituted-3-(4-(4-Substituted Phenyl)Thiazol-2-yl)-3,4-Dihydro-2H-Benzo [E][1,3] Oxazine have been prepared from 2-amino 4-substituted Phenyl thiazole react with substituted salicyladehyde results in 2,4-disubstituted-6-((4-(4- substituted phenyl) thiazol-2-ylimino) methyl) phenol. Then reacted with NaBH4, it give 2,4-disubstituted-6-((4-(4-substituted phenyl) thiazol-2-ylamino) methyl) phenol. Which is reacted with fomalin in chloroform yields 6, 8-Disubstituted-3-(4-(4-Substituted Phenyl) Thiazol-2-yl)-3,4-Dihydro-2H-Benzo [E][1,3] Oxazine. All the title compounds characterised on the basis of their MASS, 1H NMR spectroscopic data analysis.

Keywords


Synthesis, Thiazole, Salicyladehyde, Anti-Bacterial Activity.