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Spectrophotometric Estimation of Valsartan in Tablet Dosage Form


Affiliations
1 Shri Ram Institute of Technology, Near ITI, Madhotal, Jabalpur-482002 (M.P.), India
     

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Valsartan, an angiotensin receptor blocker, has been widely used for the treatment of hypertension, heart failure and heart attacks. Two rapid, sensitive and reliable UV-Spectrophotometric (Method A) and first order derivative (Method B) have been developed for estimation of valsartan in bulk and tablet. In methanol, the λmax of valsartan was found to be 249 nm. The same spectra was derivatised into first order derivative, at Δλ=2; the amplitude of the through was measured at 268 nm. The linear concentration ranges were 5-50 μg/ml for both the methods. The results of analysis were validated statistically. The Relative standard deviations for all the parameters were found to be less then the 5%. The method herein described can be employed for quality control and routine analysis of drugs in pharmaceutical formulations.

Keywords

Valsartan, First Order Derivative Method, UV Spectrophotometric Method.
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  • Spectrophotometric Estimation of Valsartan in Tablet Dosage Form

Abstract Views: 189  |  PDF Views: 0

Authors

M. Sharma
Shri Ram Institute of Technology, Near ITI, Madhotal, Jabalpur-482002 (M.P.), India
A. Sharma
Shri Ram Institute of Technology, Near ITI, Madhotal, Jabalpur-482002 (M.P.), India
A. Jain
Shri Ram Institute of Technology, Near ITI, Madhotal, Jabalpur-482002 (M.P.), India
P. S. Banerjee
Shri Ram Institute of Technology, Near ITI, Madhotal, Jabalpur-482002 (M.P.), India

Abstract


Valsartan, an angiotensin receptor blocker, has been widely used for the treatment of hypertension, heart failure and heart attacks. Two rapid, sensitive and reliable UV-Spectrophotometric (Method A) and first order derivative (Method B) have been developed for estimation of valsartan in bulk and tablet. In methanol, the λmax of valsartan was found to be 249 nm. The same spectra was derivatised into first order derivative, at Δλ=2; the amplitude of the through was measured at 268 nm. The linear concentration ranges were 5-50 μg/ml for both the methods. The results of analysis were validated statistically. The Relative standard deviations for all the parameters were found to be less then the 5%. The method herein described can be employed for quality control and routine analysis of drugs in pharmaceutical formulations.

Keywords


Valsartan, First Order Derivative Method, UV Spectrophotometric Method.