Asian Journal of Research in Chemistry

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Synthesis and Biological Evaluation of New Benzothiazole Derivatives


Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, India
     

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A series of 2-N-acetyl-[2’-(thieno substituted aryl ketone)-5’-methyl-1’,3’,4’-oxadiazolyl] benzothiazole (5a-e) have been synthesized. These structures are determined by the elemental analysis and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus ATCC 3750, Salmonella typhi NCTC 786, Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404.

Keywords

2-Amino Benzothiazole, 1,3,4-Oxadiazole, Anti-Bacterial, Anti-Fungal.
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  • Synthesis and Biological Evaluation of New Benzothiazole Derivatives

Abstract Views: 148  |  PDF Views: 0

Authors

Vrushali N. Patil
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, India
Ameya Yadav
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, India
A. S. Bobade
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, India
S. V. Athlekar
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, India
L. S. Patil
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, India
Abhay Chowdhary
Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, India

Abstract


A series of 2-N-acetyl-[2’-(thieno substituted aryl ketone)-5’-methyl-1’,3’,4’-oxadiazolyl] benzothiazole (5a-e) have been synthesized. These structures are determined by the elemental analysis and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus ATCC 3750, Salmonella typhi NCTC 786, Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404.

Keywords


2-Amino Benzothiazole, 1,3,4-Oxadiazole, Anti-Bacterial, Anti-Fungal.