Asian Journal of Research in Chemistry

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Synthesis and Evaluation of Some New Substituted Phenylthiazole Derivatives and their Anticonvulsant Activity


Affiliations
1 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S., India
2 Department of Pharmacology, JNMC, Belgaum, Karnataka, India
     

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A new series of substituted phenylthiazole derivatives were synthesized and the structures of these compounds were established on the basis of spectral and elemental analysis. All the compounds were evaluated for anti-convulsant activity by Maximal Electroshock Induced Convulsions in Rats, Pentylenetetrazole- Induced Convulsions in Rats, and Strychnine Induced Convulsions in Rats methods. Compounds C1, C2, C3, C4, C5, D1, D2, D3, D4, D5, E1, E2, E3, and E4 have been found to exhibit excellent anti-convulsant activity.

Keywords

Phenylthiazole, Anti-Convulsant.
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  • Synthesis and Evaluation of Some New Substituted Phenylthiazole Derivatives and their Anticonvulsant Activity

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Authors

Shashikant R. Pattan
Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S., India
Nachiket S. Dighe
Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S., India
Anand A. Bukitagar
Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S., India
Prerana A. Chavan
Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S., India
Snehlata K. Tambe
Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S., India
Deepak S. Musmade
Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, M.S., India
S. V. Hiremath
Department of Pharmacology, JNMC, Belgaum, Karnataka, India

Abstract


A new series of substituted phenylthiazole derivatives were synthesized and the structures of these compounds were established on the basis of spectral and elemental analysis. All the compounds were evaluated for anti-convulsant activity by Maximal Electroshock Induced Convulsions in Rats, Pentylenetetrazole- Induced Convulsions in Rats, and Strychnine Induced Convulsions in Rats methods. Compounds C1, C2, C3, C4, C5, D1, D2, D3, D4, D5, E1, E2, E3, and E4 have been found to exhibit excellent anti-convulsant activity.

Keywords


Phenylthiazole, Anti-Convulsant.