Asian Journal of Research in Chemistry

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Potassium Ferricynide and Ferric Chloride:A Chromogenic Reagent for Estimation of Tranexamic Acid by Spectrophotometry


Affiliations
1 M.E.S. College of Pharmacy, Sonai-414105, Ahmednagar, Maharashtra, India
2 MP Patel College of Pharmacy, Kapadwanj, Gujarat, India
     

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A simple, accurate and reproducible spectrophotometric method has been developed for the estimation of Tranexamic acid in bulk and pharmaceutical dosage formulations. The developed method is based on the formation of condensation product of drug with ferric chloride and potassium ferricynide, which shows absorbance maximum at 710 nm. The proposed method showed linearity in the range of 2-20 ug/ml. Results were statistically validated and were found to be reproducible. Recovery studies indicate that the method is accurate.

Keywords

Tranexamic Acid, Ferric Chloride, Potassium Ferricyanide, Spectrophotometric Method.
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  • Potassium Ferricynide and Ferric Chloride:A Chromogenic Reagent for Estimation of Tranexamic Acid by Spectrophotometry

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Authors

P. B. Mohite
M.E.S. College of Pharmacy, Sonai-414105, Ahmednagar, Maharashtra, India
R. B. Pandhare
M.E.S. College of Pharmacy, Sonai-414105, Ahmednagar, Maharashtra, India
S. G. Khanage
M.E.S. College of Pharmacy, Sonai-414105, Ahmednagar, Maharashtra, India
V. H. Bhaskar
MP Patel College of Pharmacy, Kapadwanj, Gujarat, India

Abstract


A simple, accurate and reproducible spectrophotometric method has been developed for the estimation of Tranexamic acid in bulk and pharmaceutical dosage formulations. The developed method is based on the formation of condensation product of drug with ferric chloride and potassium ferricynide, which shows absorbance maximum at 710 nm. The proposed method showed linearity in the range of 2-20 ug/ml. Results were statistically validated and were found to be reproducible. Recovery studies indicate that the method is accurate.

Keywords


Tranexamic Acid, Ferric Chloride, Potassium Ferricyanide, Spectrophotometric Method.