Synthesis, Structure and Spectral Charectarization of Friedal Craft N-Benzylation of Isatin and Their Novel Schiff’s Bases

Isatin (1H-indole-2, 3-Dione) is synthetically versatile molecule. Erdman and Laurent first obtained it in 1841 as a product from the oxidation of indigo by nitric acid and chromic acid. Isatin (Indole 2’3 dione), its 5-halo derivatives were reacted to form the Schiff’s bases,Mannich bases and Friedal Craft Alkylation’s to form C-C, C-N, C=N bonds. From the spectral studies it reveals that the isatin were undergoes reaction at C-3 and N-1 position. The structures of the synthesized derivatives were characterized from ¹H-NMR, IR spectral data and elemental analysis. The most of the compound synthesized were shown to possess biological activity.