Synthesis and Evaluation of Some New Substituted 1, 4-Dihydropyridine Derivatives and Their Anti-Inflammatory Activity

A new series if substituted 1, 4-Dihydropyridine derivatives were synthesized and the structures of these compounds were established on the basis of spectral and elemental analysis. All the compounds were evaluated for anti-inflammatory activity by paw edema, xylene induced ear edema and cotton wool granuloma methods. Compounds C₄, C₅, C₆, C₇ and C₉ have been found to exhibit excellent anti-inflammatory activity.