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Synthesis and Biological Screening of Some Novel Coumarin Derivatives
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A new series of 7-methoxy-4-methyl-8-[5-(substituted aryl) isoxazol-3-yl]–2H–benzopyran-2-ones were synthesized by cyclisization of chalcones, 8-(2-substituted prop-2-ene)-7-methoxy-4-methyl-2H-benzopyran-2-ones with hydroxylamine hydrochloride. The chalcones were synthesized starting from 7-hydroxy-4-methyl coumarin in 4 steps. The structures of the synthesized compounds have been established on the basis of physical and spectral data and are screened for anti microbial and anti inflammatory activities;some of them exhibited significant activity.
Keywords
Benzopyran, Coumarin, Antimicrobial and Anti Inflammatory.
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