Simultaneous Spectrophotometric Estimation of Ofloxacin and Ornidazole in Tablet Dosage Form

Two simple, sensitive, accurate and economical spectrophotometric methods were developed for the estimation of ofloxacin and ornidazole simultaneously in tablet dosage form. First method is based on the simultaneous equations and second method is based on Q-analysis (absorbance ratio method). Ofloxacin and ornidazole shows absorbance maxima at 294 nm and 317 nm in N/2 acetic acid, respectively. The linearity was obtained in the concentration range of 2-10 μg/ml for ofloxacin and 2-30 μg/ml for ornidazole. In the first method, the concentrations of the drugs were determined by using simultaneous equations; and in the second method, the concentrations of the drugs were determined by using ratio of absorbance at isoabsorptive point and at the λmax of the one drug. The results of analysis have been validated statistically and by recovery studies.