Simultaneous Spectrophotometric Estimation of Ezetimibe and Atorvastatin in Pharmaceutical Dosage Form

Two simple, sensitive accurate, precise, rapid and economical methods were developed for the estimation of Ezetimibe and Atorvastatin in two components solid dosage form. First method is based on simultaneous equations and second method is based on absorbance ratio method. Ezetimibe has absorbance maxima at 232.5 nm and Atorvastatin has Absorbance maxima at 246.5 nm in methanol. The linearity was obtained in the concentration range 5-30 mcg/ml for both Ezetimibe and Atorvastatin. In the first method the concentration of the drugs were determined by using simultaneous equations and in second method, concentration of the drugs were determined by using ratio of absorbance at iso-absorptive point and at λ_max of one of the drug. The results of analysis have been validated statistically and by recovery studies.