Spectrophotometric Methods for Simultaneous Estimation of Dexibuprofen and Paracetamol

Three simple spectrophotometric methods have been developed for simultaneous estimation of dexibuprofen and paracetamol from tablet dosage form. Ethanol (95%) was used as solvent. Method-I involves, formation of Q-absorbance equation at 235.5 nm (isoabsorptive point) and 249.5 nm (λ_max of paracetamol); Method-II simultaneous equation method involves the measurement of absorbances at two wavelengths 223 nm (λ_max of dexibuprofen) and 249.5 nm (λ_max of paracetamol) and Method-III multicomponent mode of analysis involves the measurement of absorbances at two wavelengths 223 nm (λ_max of dexibuprofen) and 249.5 nm (λ_max of paracetamol); The linearity lies between 2-7 μg/ml for dexibuprofen and 4-14 μg/ml for paracetamol for all the three methods. The accuracy and precision of the methods were determined and validated stastically. All the methods showed good reproducibility and recovery with % RSD less than 1. All method were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of dexibuprofen and paracetamol in bulk and combined dosage form.