Asian Journal of Research in Chemistry

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Synthetic and Pharmacological Evaluation of Some Pyridine Containing Thiazolidinones


Affiliations
1 KYDSCT’s College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S), India
2 TVES’s College of Pharmacy, Faizpur, Tal. Yawal, Dist. Jalgaon, (M.S), India
     

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A series of N’-[3-(aryl/alkyl substituted)-4-oxo-1, 3-thiazolidin-2-ylidene]-2-(pyridine-2-yloxy) acetohydrazides were synthesized using appropriate synthetic route. These compounds were synthesized by their analytical and spectral data. All the newly synthesized compounds were examined for their antidiabetic activity using GOD-POD method on Wistar strain rats. The acute toxicity study (LD50) values of these compounds were determined. The test compounds showed significant antidiabetic activity on evaluation.

Keywords

Thiazolidinone, Pyridine, Antidiabetic Activity.
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  • Synthetic and Pharmacological Evaluation of Some Pyridine Containing Thiazolidinones

Abstract Views: 271  |  PDF Views: 0

Authors

S. D. Firke
KYDSCT’s College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S), India
B. M. Firake
KYDSCT’s College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon, (M.S), India
R. Y. Chaudhari
TVES’s College of Pharmacy, Faizpur, Tal. Yawal, Dist. Jalgaon, (M.S), India
V. R. Patil
TVES’s College of Pharmacy, Faizpur, Tal. Yawal, Dist. Jalgaon, (M.S), India

Abstract


A series of N’-[3-(aryl/alkyl substituted)-4-oxo-1, 3-thiazolidin-2-ylidene]-2-(pyridine-2-yloxy) acetohydrazides were synthesized using appropriate synthetic route. These compounds were synthesized by their analytical and spectral data. All the newly synthesized compounds were examined for their antidiabetic activity using GOD-POD method on Wistar strain rats. The acute toxicity study (LD50) values of these compounds were determined. The test compounds showed significant antidiabetic activity on evaluation.

Keywords


Thiazolidinone, Pyridine, Antidiabetic Activity.