Asian Journal of Research in Chemistry

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A Rapid, Convenient Microwave assisted and Conventional Synthesis of Novel Azetidin-2-One Derivatives as Potent Antimicrobial Agents


Affiliations
1 Department of Pharmaceutical Chemistry, Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar (Gujarat), India
2 Department of Chemistry, Veer Narmad South Gujarat University, Udhna-Magdalla Road, Surat (Gujarat), India
     

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We report efficient and extremely fast procedures for the synthesis of 3-chloro-4-(4-(diethylamino)-2-hydroxyphenyl)- 1-(substitutedphenyl)-azetidin-2-one using 4-diethylamino-2-hydroxybenzaldehyde, various amines and chloroacetyl chloride in presence of triethylamine under microwave irradiation (w) and similarly, conventional methods are used for comparison. A considerable increase in the reaction rate has been observed with better yield in microwave technique. The structures of the compounds were confirmed by elemental analysis and spectral analysis (1H-NMR, 13CNMR and Mass). All the compounds have been screened for their antifungal activity and their antibacterial activity against various gram +ve and gram –ve bacteria.

Keywords

4-Diethylamino-2-Hydroxybenzaldehyde, Azetidin-2-One, Microwave Method, Antimicrobial Activity.
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  • A Rapid, Convenient Microwave assisted and Conventional Synthesis of Novel Azetidin-2-One Derivatives as Potent Antimicrobial Agents

Abstract Views: 248  |  PDF Views: 0

Authors

Jignesh P. Raval
Department of Pharmaceutical Chemistry, Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar (Gujarat), India
Hemul V. Patel
Department of Pharmaceutical Chemistry, Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar (Gujarat), India
Pradip S. Patel
Department of Pharmaceutical Chemistry, Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar (Gujarat), India
Nilesh H. Patel
Department of Pharmaceutical Chemistry, Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences, New Vallabh Vidyanagar (Gujarat), India
Kishor R. Desai
Department of Chemistry, Veer Narmad South Gujarat University, Udhna-Magdalla Road, Surat (Gujarat), India

Abstract


We report efficient and extremely fast procedures for the synthesis of 3-chloro-4-(4-(diethylamino)-2-hydroxyphenyl)- 1-(substitutedphenyl)-azetidin-2-one using 4-diethylamino-2-hydroxybenzaldehyde, various amines and chloroacetyl chloride in presence of triethylamine under microwave irradiation (w) and similarly, conventional methods are used for comparison. A considerable increase in the reaction rate has been observed with better yield in microwave technique. The structures of the compounds were confirmed by elemental analysis and spectral analysis (1H-NMR, 13CNMR and Mass). All the compounds have been screened for their antifungal activity and their antibacterial activity against various gram +ve and gram –ve bacteria.

Keywords


4-Diethylamino-2-Hydroxybenzaldehyde, Azetidin-2-One, Microwave Method, Antimicrobial Activity.