Asian Journal of Research in Chemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Method Development and Validation for estimation of Trihexyphenedyl Hydrochloride in Tablet Dosage Forms


Affiliations
1 B.A. Research House, Opposite Pushpraj Towers, Near Judges bunglows, Ahmedabad- 380054, India
2 B.R. Nahata College of Pharmacy, Mhu-Neemuch Road, Mandsaur (M.P)-458001, India
3 Lachoo College of Science and Technology, Shastri Nagar, sector A, Jodhpur (Rajasthan), India
     

   Subscribe/Renew Journal


The development and validation of Trihexyphenidyl Hydrochloride was carried out by Ion pair extraction method. The estimation was measure at 410 nm. Against blank preparation and calibration curve was plotted. The Beer’s Law was linear in concentration range of 2μg/ml to 18 μg/ml at 410 nm. The method developed was validated to determine its accuracy, precision and specificity. The recovery study was carried out by standard addition method.

Keywords

Trihexyphenidyl Hydrochloride, Ion Pair Extraction Method , Bromocresol Green.
Subscription Login to verify subscription
User
Notifications
Font Size


Abstract Views: 167

PDF Views: 0




  • Method Development and Validation for estimation of Trihexyphenedyl Hydrochloride in Tablet Dosage Forms

Abstract Views: 167  |  PDF Views: 0

Authors

Ashwin Patel
B.A. Research House, Opposite Pushpraj Towers, Near Judges bunglows, Ahmedabad- 380054, India
Alankar Shrivastava
B.R. Nahata College of Pharmacy, Mhu-Neemuch Road, Mandsaur (M.P)-458001, India
Anurekha Jain
B.R. Nahata College of Pharmacy, Mhu-Neemuch Road, Mandsaur (M.P)-458001, India
G. K. Singh
Lachoo College of Science and Technology, Shastri Nagar, sector A, Jodhpur (Rajasthan), India

Abstract


The development and validation of Trihexyphenidyl Hydrochloride was carried out by Ion pair extraction method. The estimation was measure at 410 nm. Against blank preparation and calibration curve was plotted. The Beer’s Law was linear in concentration range of 2μg/ml to 18 μg/ml at 410 nm. The method developed was validated to determine its accuracy, precision and specificity. The recovery study was carried out by standard addition method.

Keywords


Trihexyphenidyl Hydrochloride, Ion Pair Extraction Method , Bromocresol Green.