Asian Journal of Research in Chemistry

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Development and Validation of UV Spectrophotometric Method of Cefuroxime Axetil in Bulk and Pharmaceutical Formulation


Affiliations
1 Yash Institute of Pharmacy, South City, Bajaj Nagar, Post Box no. 968, Waluj, Aurangabad-431134, India
2 Y.B.Chavan College of Pharmacy, Maulana Azad Education Trust, Dr. Rafiq Zakaria Marg, Aurangabad-431001, India
     

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A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of cefuroxime axetil in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on measurement of absorption at maximum wavelength 281nm.The percentage recovery of cefuroxime axetil ranged from (99.97 ± 0.3969) in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 4-28μg/ml having line equation y = 0.0346x + 0.0566 with correlation coefficient of 0.9999. Results of the analysis were validated statistically and by recovery study.

Keywords

UV Spectrophotometry, Cefuroxime Axetil.
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  • Development and Validation of UV Spectrophotometric Method of Cefuroxime Axetil in Bulk and Pharmaceutical Formulation

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Authors

Santosh Shelke
Yash Institute of Pharmacy, South City, Bajaj Nagar, Post Box no. 968, Waluj, Aurangabad-431134, India
Santosh Dongre
Yash Institute of Pharmacy, South City, Bajaj Nagar, Post Box no. 968, Waluj, Aurangabad-431134, India
Amit Rathi
Y.B.Chavan College of Pharmacy, Maulana Azad Education Trust, Dr. Rafiq Zakaria Marg, Aurangabad-431001, India
Dinesh Dhamecha
Y.B.Chavan College of Pharmacy, Maulana Azad Education Trust, Dr. Rafiq Zakaria Marg, Aurangabad-431001, India
Saifee Maria
Y.B.Chavan College of Pharmacy, Maulana Azad Education Trust, Dr. Rafiq Zakaria Marg, Aurangabad-431001, India
Mohd Hassan G. Dehghan
Y.B.Chavan College of Pharmacy, Maulana Azad Education Trust, Dr. Rafiq Zakaria Marg, Aurangabad-431001, India

Abstract


A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of cefuroxime axetil in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on measurement of absorption at maximum wavelength 281nm.The percentage recovery of cefuroxime axetil ranged from (99.97 ± 0.3969) in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 4-28μg/ml having line equation y = 0.0346x + 0.0566 with correlation coefficient of 0.9999. Results of the analysis were validated statistically and by recovery study.

Keywords


UV Spectrophotometry, Cefuroxime Axetil.