Asian Journal of Research in Chemistry

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Synthesis and Evaluation of Some New Thiazolidinedione Derivatives for Their Antidiabetic Activities


Affiliations
1 Dept. of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, India
2 Department of Medicinal Chemistry, K.L.E.S.’s College of Pharmacy, Belgaum 590 010, India
3 Dept. of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, India
4 Dept. of Pharmaceutical Chemistry, Y B Chavan College of Pharmacy, Aurangabad, India
     

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A new series of thiazolidinedione derivatives were synthesized by reacting under microwave irradiation. The structures of these compounds were established by means of IR, 1H-NMR and elemental analysis. All the compounds (B1-B9) were screened for antidiabetic activity on albino rats. Most of these compounds have shown significant antidiabetic activity when compared with the standard drug glibenclamide.

Keywords

Thiazolidinedione, Antidiabetic Activity, Microwave Assisted Synthesis.
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  • Synthesis and Evaluation of Some New Thiazolidinedione Derivatives for Their Antidiabetic Activities

Abstract Views: 241  |  PDF Views: 0

Authors

R. Pattan Shashikant
Dept. of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, India
Kekare Prajact
Department of Medicinal Chemistry, K.L.E.S.’s College of Pharmacy, Belgaum 590 010, India
N. S. Dighe
Dept. of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, India
S. B. Bhawar
Dept. of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, India
Nikalje Ana
Dept. of Pharmaceutical Chemistry, Y B Chavan College of Pharmacy, Aurangabad, India
Pati Ashwini
Dept. of Pharmaceutical Chemistry, Y B Chavan College of Pharmacy, Aurangabad, India
M. B. Hole
Dept. of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, India

Abstract


A new series of thiazolidinedione derivatives were synthesized by reacting under microwave irradiation. The structures of these compounds were established by means of IR, 1H-NMR and elemental analysis. All the compounds (B1-B9) were screened for antidiabetic activity on albino rats. Most of these compounds have shown significant antidiabetic activity when compared with the standard drug glibenclamide.

Keywords


Thiazolidinedione, Antidiabetic Activity, Microwave Assisted Synthesis.