New Spectrophotometric Determination of Cefaclor in Bulk Drug and Synthetic Mixture

A simple, economic and reproducible spectroscopic method has been developed for the determination of cefaclor API and in its pharmaceutical formulations. The spectroscopic method is based on the formation of complex with p-di methyl amino benzaldehyde reagent having absorbance maxima at 484.4 nm. Optimization of reaction was carried out with the factors: buffer strength, reaction time, stability of complex, molar ratio of drug: reagent. The Beer-Lambert’s law was followed in the range of 2.5-15 μg/ml.