Asian Journal of Research in Chemistry

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Biological Activity of Some (2E)-Substituted-2-Ethylidene-5,6-Diphenylimidazo[2,1-b][1,3] Thiazol-3-(2H)-Ones


Affiliations
1 M.P. Patel College of Pharmacy, Kapadwanji, Gujarat-3876202, India
2 Medicinal Plant Research Centre, Vinayaka Mission’s College of Pharmacy, Vinayaka Missions University, Salem-636008, Tamil Nadu, India
     

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Certain (2E)-substituted-2-ethylidene-5,6-diphenylimidazo[2,1-b][1,3]thiazol-3-(2H)-ones (4a-f) have been synthesized by the condensation of 4,5-diphenylimidazoin-2-thiones (3) with different aromatic aldehydes and chloroacetic acid in presence of acetic anhydride, anhydrous sodium acetate and glacial acetic acid. These compounds were characterized by their analytical and spectral data. The title compounds were found to be efficient antibacterial agents on evaluation.

Keywords

Imidazothiazole, Biological Activity, Antibacterial Activity.
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  • Biological Activity of Some (2E)-Substituted-2-Ethylidene-5,6-Diphenylimidazo[2,1-b][1,3] Thiazol-3-(2H)-Ones

Abstract Views: 233  |  PDF Views: 0

Authors

V. H. Bhaskar
M.P. Patel College of Pharmacy, Kapadwanji, Gujarat-3876202, India
M. Kumar
Medicinal Plant Research Centre, Vinayaka Mission’s College of Pharmacy, Vinayaka Missions University, Salem-636008, Tamil Nadu, India
B. R. Balakrishnan
Medicinal Plant Research Centre, Vinayaka Mission’s College of Pharmacy, Vinayaka Missions University, Salem-636008, Tamil Nadu, India
B. Sangameswaran
Medicinal Plant Research Centre, Vinayaka Mission’s College of Pharmacy, Vinayaka Missions University, Salem-636008, Tamil Nadu, India

Abstract


Certain (2E)-substituted-2-ethylidene-5,6-diphenylimidazo[2,1-b][1,3]thiazol-3-(2H)-ones (4a-f) have been synthesized by the condensation of 4,5-diphenylimidazoin-2-thiones (3) with different aromatic aldehydes and chloroacetic acid in presence of acetic anhydride, anhydrous sodium acetate and glacial acetic acid. These compounds were characterized by their analytical and spectral data. The title compounds were found to be efficient antibacterial agents on evaluation.

Keywords


Imidazothiazole, Biological Activity, Antibacterial Activity.