Asian Journal of Research in Chemistry

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A Validated Potentiometric Titration Method for Quantitative Determination of Favipiravir from Pharmaceutical Preparation


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1 Central Research Laboratory D.G. Ruparel College Mahim, Mumbai 400 016., India
     

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A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of favipiravir from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 10 % to 50 % w/v of 0.200 mg of drug substance weight. The percentage recovery of favipiravir in the optimized method was between 99.65 to 100.08 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

Keywords

Favipiravir, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid.
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  • A Validated Potentiometric Titration Method for Quantitative Determination of Favipiravir from Pharmaceutical Preparation

Abstract Views: 133  |  PDF Views: 0

Authors

Rele Rajan V
Central Research Laboratory D.G. Ruparel College Mahim, Mumbai 400 016., India
Tiwatane Prathamesh P
Central Research Laboratory D.G. Ruparel College Mahim, Mumbai 400 016., India

Abstract


A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of favipiravir from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 10 % to 50 % w/v of 0.200 mg of drug substance weight. The percentage recovery of favipiravir in the optimized method was between 99.65 to 100.08 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

Keywords


Favipiravir, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid.

References