Asian Journal of Research in Chemistry

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Elaboration and Physicochemical characterization of a Biomaterial for Bone Substitution


Affiliations
1 Applied Chemistry Laboratory, Mohammd Kheidar University., Biskra, Algeria., India
2 Valorisation and Promotion of Saharan Resources Laboratory (VPRS), Chemistry Department, Faculty of Mathematics and Material Sciences, Kasdi Merbah University, Ouargla, Algeria., India
3 alorisation and Promotion of Saharan Resources Laboratory (VPRS), Chemistry Department, Faculty of Mathematics and Material Sciences, Kasdi Merbah University, Ouargla, Algeria., India
4 Applied Chemistry Laboratory, Mohammd Kheidar University., Biskra, Algeria ., India
     

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Hydroxyapatite like other related calcium phosphate minerals, has been used extensively as an orthopedic implant material for many years due to its excellent biocompatibility, bone bonding ability and also due to its structural and compositional similarity to that of the mineral phase of hard tissue in human bones. Therefore, in this study, HA has been synthesized using calcium hydroxide Ca(OH)2 and di-ammonium hydrogen phosphate (NH4)2HPO4 as calcium and phosphate precursors, respectively. The hydroxyapatite powders were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscope (SEM) in conjunction with energy dispersive x-ray spectroscopy (EDX) and measuring of density to provide information about crystal structure, composition, functional group distribution, and morphology.

Keywords

Hydroxyapatite, calcium hydroxide, Crystal structure, Fourier transform infrared, X-ray diffraction
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  • Sadat S. M. Khorasani M. Dinpanah K. E. Jamshidi A. Synthesis methods for nanosized hydroxyapatite in diverse structures 2013; 9(8): 7591-7621. Acta Biomaterialia.

  • Ratner B. D. Hoffman A. S. Schoen F. J. Lemons J. E.. An Introduction to Materials in Medicine, 2004; Biomaterials Science:, Elsevier Academic Press.

  • Grynpas M.D.. Omelon S. Transient precursor strategy or very small biological apatite crystals? Bone. 2007; 41:162–164

  • Weiner S. Wagner H.D.. The material bone: Structure-mechanical function relations. 1998; Ann. Rev. Mater. Sci. ; 28:271–298.

  • Dorozhkin S.V. Epple M.. Biological and medical significance of calcium phosphates. Angew. 2002; Chem. Int. Ed.; 41:3130–3146.

  • Currey J.D. . Bones: Structure and Mechanics. 2002; Princeton University Press; Princeton, NJ, USA:.

  • Fratzl P. Gupta H.S. Paschalis E.P.. Roschger P. Structure and mechanical quality of the collagen-mineral nano-composite in bone. 2004; J. Mater. Chem. ;14:2115–2123

  • Weiner S. 2006. Transient precursor strategy in mineral formation of bone. Bone. ;39:431–433.

  • Kerr J. B.. Atlas of functional histology, London: 2000; Harcourt Publishers.

  • Hing K. A.. Bone repair in the twenty–first century: biology, chemistry or engineering?. 2004; 362 : 2821-2850.DOI:10.1098/rsta.2004.1466.

  • Faweett D. W. A Textbook of Histology. 1986London: W. B.Company.

  • Shi, D. 2011. Biomaterials and tissue engineering, Berlin: Springer.

  • Himanshu K et Satya P. 2016. Synthesis and Characterization of Hydroxyapatite Powder by Eggshell. Journal of Minerals and Materials Characterization and Engineering 4 : 119-126.

  • Erdman N., Bell D. C. Reichelt R. 2019. Scanning Electron Microscopy. in Handbook of Microscopy, Springer.

  • Pathak Y. V. 2016. Handbook of metallonutraceuticals, CRC Press.

  • Kribaa O K, Boutarfaia A, The Study of Reaction Sequences for Formation of Solid Solution of Ceramic Material: Pb12XSmxNdx[(Zr0,55Ti0,45)1-0.02,0.01(Y2/3,Mo1/3),0.01 (Y2/3,Ni1/3)]O3 and the Study of These Structures. Journal of Minerals and Materials Characterization and Engineering. 2013; 1, 217-221. DOI: 10.4236/jmmce.2013.15034.

  • Leung, Y., Walters, M.A., LeGeros, R.Z., Second derivative infrared spectra of hydroxyapatite. Spectrochim, Spectroc. Acta. 46 (1990) 1453-1459.

  • Baddiel, C.B., Berry, E.E., Spectra Structure Correlations in Hydroxy and Fluorapatite., Spectrochim. Acta. 22(1966) 1407

  • Nakamoto K., Infrared and Raman Spectra of Inorganic and Coordination Compounds., Chichester, Brisbane, Toronto (2008), John Wiley & Sons, Inc.. DOI:10.1002/9780470405840

  • Legeros, R.Z., Bonel, G., Legros, R., The unit-cell dimensions of human enamel apatite: effect of chloride ... The moisture content of calcified tooth tissues, Types of “H2O” in human enamel and in

  • precipitated apatites. Calcif. Tissue Res. 1978; 26, 111–118.

  • Kribaa Ou K, Boutarfaia A, “The Study of a New Ceramic PZT Material Pb1-0.04Sm0.02Nd0.02[(Zr0.55, Ti0.45)1-2x, x(Y2/3, Mo1/3), x(Y2/3,Ni1/3)]O3 with SEM and X-Ray Diffraction “Materials Sciences and Applications, 2013; 4, 595-599.DOI :10.4236/msa.2013.410073.

  • Kribaa O. K, Souha L, Saifi F., and Chahbaoui, N. 'Elaboration and chemical characterization of a composite material based on hydroxyapatite/polyethylene'. Materials Today: Proceedings. 2021

  • ; doi:10.1016/j.matpr.2021.08.120


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  • Elaboration and Physicochemical characterization of a Biomaterial for Bone Substitution

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Authors

Kribaa O K
Applied Chemistry Laboratory, Mohammd Kheidar University., Biskra, Algeria., India
Zenkhri L
Valorisation and Promotion of Saharan Resources Laboratory (VPRS), Chemistry Department, Faculty of Mathematics and Material Sciences, Kasdi Merbah University, Ouargla, Algeria., India
Boutarfaia A
Applied Chemistry Laboratory, Mohammd Kheidar University., Biskra, Algeria., India
Ben Amor L
alorisation and Promotion of Saharan Resources Laboratory (VPRS), Chemistry Department, Faculty of Mathematics and Material Sciences, Kasdi Merbah University, Ouargla, Algeria., India
Chahbaoui N
Applied Chemistry Laboratory, Mohammd Kheidar University., Biskra, Algeria ., India

Abstract


Hydroxyapatite like other related calcium phosphate minerals, has been used extensively as an orthopedic implant material for many years due to its excellent biocompatibility, bone bonding ability and also due to its structural and compositional similarity to that of the mineral phase of hard tissue in human bones. Therefore, in this study, HA has been synthesized using calcium hydroxide Ca(OH)2 and di-ammonium hydrogen phosphate (NH4)2HPO4 as calcium and phosphate precursors, respectively. The hydroxyapatite powders were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscope (SEM) in conjunction with energy dispersive x-ray spectroscopy (EDX) and measuring of density to provide information about crystal structure, composition, functional group distribution, and morphology.

Keywords


Hydroxyapatite, calcium hydroxide, Crystal structure, Fourier transform infrared, X-ray diffraction

References