Asian Journal of Research in Chemistry

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Synthesis, Characterization, UTI and Antibacterial Activity of Schiff Base, (E)-2-(decan-2-ylidene) hydrazine-1-carboxamide Co2+, Mn2+ and Fe3+Metal Complexes


Affiliations
1 Department of Chemistry, Banasthali Vidyapith, Tonk – Newai, Rajasthan – 304022, India
     

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Novel coordination complexes of Co, Mn and Fe with Azomethine (E)-2-(decan-2-ylidene) hydrazine-1- carboxamide have been synthesized and studied using elemental analysis (C, H, N), FT-IR, 1HNMR, 13 CNMR, XRD and Mass spectroscopy as well as thermal studies. The Schiff base has octahedral geometry and functions as a tridentate ONS donor ligand. The antimicrobial action of the Azomethine ligand and complexes was investigated towards Staphylococcus aureus, Escherichia coli and fungi C. albicans and A. fumigatus. Microbial pathogens invading the urinary tract produced urinary tract infections, they can cause a variety of clinical symptoms as well as potentially fatal sequelae. The current research focus on the growth of a novel antimicrobial agent towards E. coli, P. aeruginosa, K. pneumoniae bacteria.

Keywords

Schiff bases, IR spectra, NMR spectra, Mass spectra, Anti-microbial and UTI activity.
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  • Da Silva, C. M.; da Silva, D. L.; Modolo, L. V.; Alves, R. B.; de Resende, M. A.; Martins, C. V.; de Fátima, Â., Schiff bases: A short review of their antimicrobial activities. Journal of Advanced Research. 2011, 2, 1-8.

  • Katwal, R.; Kaur, H.; Kapur, B. K., Applications of copper— Schiff’s base complexes: a review. Scientific Review and Chemical Communications. 2013, 3, 1-15.

  • Mahmud, T., Synthesis and characterization of the amino acid Schiff bases and their complexes with copper (II). 2010.

  • Bader, N. R., Applications of Schiff’s Bases Chelates in Quantitative Analysis A Review. Rasayan Journal of Chemistry. 2010, 3, 660-70.

  • Maher, K.; Mohammed, S., Metal complexes of Schiff base derived from salicylaldehyde-A review. International Journal of Current Research and Review. 2015, 7, 6.

  • Al Zoubi, W., Biological activities of Schiff bases and their complexes: a review of recent works. International Journal of Organic Chemistry. 2013, 2013.

  • Patil CJ, Manisha C, Patil, Patil MC. Studies on Synthesis of Aromatic Schiff Bases. Part-V. Evaluation of Antifungal Potential of Ketimines from 5-Chloro-2-hydroxy-4-methyl-acetophenone.Asian Journal of Research in Chemistry. 2018; 10(2): 125-130.

  • S.B. Junne, Archana B. Kadam, Archana Y. Vibhute, S.L. Shinde, R.B. Patil, Y.B. Vibhute Reduction of Schiff Bases with Sodium Borohydride Possessing Antibacterial Activity. Asian Journal of Research in Chemistry. 2010; 3(3): 578-580.

  • Hanmanthu G, Srinivas N, Shravankumar K, Ravinder V. Synthesis and Antibacterial Studies of Schiff bases derived from ophthalaldehyde. Asian J. Research Chem. 2015; 8(8): 530-534.

  • Monica A, J. Saravanan, Mohan S, Shivaji B. Synthesis, Characterization and Antimicrobial Activity of Some Schiff Bases of 2-amino-4-(4-chlorophenyl)–n-(3-furan-2-ylmethyl carboxamido) thiophenes. Asian Journal of Research Chemistry 2013; 6(1): 24-28.

  • Shivaji B, Monica A, Saravanan J, Moha S. Synthesis, Characterization and Antimicrobial Activity of Some Schiff Bases of 2-Amino-N-(o-Fluorophenylcarboxamido)-4-(pMethoxyphenyl) Thiophenes. Asian Journal of Research Chemistry. 2012; 5(11): 1399-1404.

  • Dhanaraju MD, Gopi C, Sastry VG. Synthesis and Biological Evaluation of Some 4-(5 ((1h-Benzo [D][1, 2, 3] Triazol-1-Yl) Methyl)-1, 3, 4-Oxadiazol-2yl)-N Benzylidenebenamine Derivative as a Anti-Microbial and Anti-Convulsant Agents. Asian Journal of Research in Chemistry. Asian Journal of Research in Chemistry. 2015; 8: 459-464.

  • Kavitha PN, Mohan S, Saravanan J, Subhajit D. Microwave Assisted Synthesis, Characterization and Antimicrobial Activity of Some Schiff Bases of 2- Amino (4- Chloro Phenyl) Thiazoles.Asian Journal of Research Chemistry. 2010; 3(3): 751-754.

  • Roopa HR, Saravanan J, Mohan S, Rekha P. Synthesis, Characterization and Anti-Inflammatory Activity of Some Schiff bases of 4-Amino-5,6-Dimethyl thieno [2,3-d] Pyrimidines. Asian Journal of Research Chemistry. 2015; 8(3): 213- 217.

  • Alok P, Shekhar V, Ravindra DD, Dhansay D, Vidyanand P, Keshav D. Synthesis, Analgesic and Anti-Inflammatory Activities of Novel Schiff Bases of 2-Amino-5-Aryl-1, 3, 4-Thiadiazole.Asian Journal of Research Chemistry. 2011; 4(2): 278-281.

  • Surakanti R, Eppakayala L, Ramchander M, Venkat RP. Synthesis and molecular docking for anti-inflammatory and anti-mitotic activities of (S)-(2-Methyl-4-(1-Phenyl-1h-Thieno/Furan [3, 2-C] Pyrazol-3-yl) Piperazin-1-yl)(Pyridin-2-yl) Methanone. Asian Journal of Research in Chemistry. 2017;10(4):582-586.

  • Kumar, D.; Sharma, N.; Nair, M., Synthesis, spectral and extended spectrum beta-lactamase studies of transition metal tetraaza macrocyclic complexes. Journal of Biological Inorganic Chemistry.2017, 1-9.

  • Sheerin, N. S.; Glover, E. K., Urinary tract infection. Medicine.2019, 47,546–550.

  • Sheerin, N. S., Urinary tract infection. Medicine. 2011, 39,384– 389.

  • Kasper, D. L.; Fauci, A. S.; Hauser, S. L.; Longo, D. L.; Jameson, J. L.; Loscalzo, J., Urinary tract infections, pyelonephritis, and prostatitis. In: Harrison’s Principles of Internal Medicine, 20th edn. McGraw-Hill Education, New York, 2018.

  • Freire, M. P.; Martinho, L.; Mendes, C. V.; Spadão, F.; De Paula, F. J.; Nahas, W. C.; David-Neto, E.; Pierrotti, L. C., Institutional protocol adherence in the incidence of recurrent urinary tract infection after kidney transplantation. Journal of Global Antimicrobial Resistance. 2020, 23,352–358.

  • Olin, S. J.; Bartges, J. W., Urinary tract infections: treatment/comparative therapeutics. Vet Clin North Am Small Anim Pract. 2015, 45,721–746

  • Behzadi, P., Classical chaperone-usher (CU) adhesive fimbriome: uropathogenic Escherichia coli (UPEC) and urinary tract infections (UTIs). Folia Microbiol (Praha), 2019.

  • Khameneh, B.; Iranshahy, M.; Vahdati-Mashhadian, N.; Sahebkar, A.; Fazly Bazzaz, B. S., Non-antibiotic adjunctive therapy: a promising approach to fight tuberculosis. Pharmacol Res. 2019, 146,104-289.

  • Khameneh, B.; Diab, R.; Ghazvini, K.; Fazly Bazzaz, B. S., Breakthroughs in bacterial resistance mechanisms and the potential ways to combat them. Microb Pathog. 2016, 95:32–42.

  • Khameneh, B.; Iranshahy, M.; Soheili, V.; Fazly Bazzaz, B. S., Review on plant antimicrobials: a mechanistic viewpoint. Antimicrob Resist Infect Control. 2019, 8,1-18.

  • Kamal, T.; Ahmad, I.; Khan, S.B.; A.M. Asiri, A.M., Synthesis and catalytic properties of silver nanoparticles supported on porous cellulose acetate sheets and wet-spun fibers, Carbohydr. Polym.

  • , 157, 294-302.

  • Sobola, A. O.; Watkins, G. M., Antimicrobial activity and Cu (II) complexes of Schiff bases derived from ortho-aminophenol and salicylaldehyde derivatives. Journal of Chemical and Pharmaceutical Research. 2013, 5, 147-154.

  • Afsan, F.; Dalia, S. A.; Hossain, S.; Sarker, S., Synthesis, Spectral and Thermal Characterization of Selected Metal Complexes Containing Schiff Base Ligands with Antimicrobial Activities.

  • Asian Journal of Chemical Sciences. 2018, 1-19.

  • Chapeaurouge, A.; Bigler, L.; Schäifer, A.; Bienz, S., Correlation of stereoselectivity and ion response in electrospray massspectrometry. electrospray ionization-mass spectrometry as a tool to predict chemical behavior? Journal of the American Society for Mass Spectrometry. 1995, 6, 207-211.

  • Badea, M.; Emandi, A.; Marinescu, D.; Cristurean, E.; Olar, R.; Braileanu, A.; Budrugeac, P.; Segal, E., Thermal stability of some azo-derivatives and their complexes. Journal of Thermal Analysis

  • and Calorimetry. 2003, 72, 525-531.


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  • Synthesis, Characterization, UTI and Antibacterial Activity of Schiff Base, (E)-2-(decan-2-ylidene) hydrazine-1-carboxamide Co2+, Mn2+ and Fe3+Metal Complexes

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Authors

Anita
Department of Chemistry, Banasthali Vidyapith, Tonk – Newai, Rajasthan – 304022, India
Priyanka Ghanghas
Department of Chemistry, Banasthali Vidyapith, Tonk – Newai, Rajasthan – 304022, India
Kavita Poonia
Department of Chemistry, Banasthali Vidyapith, Tonk – Newai, Rajasthan – 304022, India

Abstract


Novel coordination complexes of Co, Mn and Fe with Azomethine (E)-2-(decan-2-ylidene) hydrazine-1- carboxamide have been synthesized and studied using elemental analysis (C, H, N), FT-IR, 1HNMR, 13 CNMR, XRD and Mass spectroscopy as well as thermal studies. The Schiff base has octahedral geometry and functions as a tridentate ONS donor ligand. The antimicrobial action of the Azomethine ligand and complexes was investigated towards Staphylococcus aureus, Escherichia coli and fungi C. albicans and A. fumigatus. Microbial pathogens invading the urinary tract produced urinary tract infections, they can cause a variety of clinical symptoms as well as potentially fatal sequelae. The current research focus on the growth of a novel antimicrobial agent towards E. coli, P. aeruginosa, K. pneumoniae bacteria.

Keywords


Schiff bases, IR spectra, NMR spectra, Mass spectra, Anti-microbial and UTI activity.

References