Asian Journal of Research in Chemistry

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Simple Extractive Spectrophotometric Method for Determination of Favipiravir from Pharmaceutical Formulation


Affiliations
1 Central Research Laboratory, D. G. Ruparel College, Mahim, Mumbai - 400 016 ., India
2 Central Research Laboratory, D. G. Ruparel College, Mahim, Mumbai - 400 016., India
     

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Simple sensitive and accurate extractive spectrophotometric methods have developed for the estimation of favipiravir in pharmaceutical dosage form. The methods are based on the formation of coloured complexes by the drug with reagents like bromophenol blue, solochrome dark blue and bromocresol green in acidic medium. The ion associated complexes were formed and quantitatively extracted under the experimental condition in chloroform. The absorbance values were measured at 420nm, 495nm and 430nm respectively. The proposed methods were validated statistically. Recoveries of methods were carried out by standard addition methods. The linearity was found to be 1.0-12.0μg/ml, 2-20μg/ml, 1-16μg/ml for methods 1, 2 and 3 respectively. The low values of standard deviation and percentage RSD indicate high precision of methods. Hence these methods are useful for routine estimation of favipiravir in tablets

Keywords

Favipiravir, Bromophenol blue, solochrome dark blue, Bromocresol green, Chloroform ethanol.
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  • Simple Extractive Spectrophotometric Method for Determination of Favipiravir from Pharmaceutical Formulation

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Authors

Rele Rajan V
Central Research Laboratory, D. G. Ruparel College, Mahim, Mumbai - 400 016 ., India
Tiwatane Prathamesh P
Central Research Laboratory, D. G. Ruparel College, Mahim, Mumbai - 400 016., India

Abstract


Simple sensitive and accurate extractive spectrophotometric methods have developed for the estimation of favipiravir in pharmaceutical dosage form. The methods are based on the formation of coloured complexes by the drug with reagents like bromophenol blue, solochrome dark blue and bromocresol green in acidic medium. The ion associated complexes were formed and quantitatively extracted under the experimental condition in chloroform. The absorbance values were measured at 420nm, 495nm and 430nm respectively. The proposed methods were validated statistically. Recoveries of methods were carried out by standard addition methods. The linearity was found to be 1.0-12.0μg/ml, 2-20μg/ml, 1-16μg/ml for methods 1, 2 and 3 respectively. The low values of standard deviation and percentage RSD indicate high precision of methods. Hence these methods are useful for routine estimation of favipiravir in tablets

Keywords


Favipiravir, Bromophenol blue, solochrome dark blue, Bromocresol green, Chloroform ethanol.

References