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A Validated Potentiometric Titration Method for Quantitative Determination of Molnupiravir from Pharmaceutical Preparation


Affiliations
1 Central Research Laboratory, D.G. Ruparel College Mahim Mumbai 400 016., India
2 Central Research Laboratory, D.G. Ruparel College Mahim Mumbai 400 016 ., India
     

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A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of molnupiravir from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 10 % to 50 % w/v of 100 mg of drug substance weight. The percentage recovery of molnupiravir in the optimized method was between 99.05 to 99.81 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

Keywords

Molnupiravir, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid.
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  • A Validated Potentiometric Titration Method for Quantitative Determination of Molnupiravir from Pharmaceutical Preparation

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Authors

Rele Rajan V
Central Research Laboratory, D.G. Ruparel College Mahim Mumbai 400 016., India
Tiwatane Prathamesh P
Central Research Laboratory, D.G. Ruparel College Mahim Mumbai 400 016 ., India

Abstract


A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of molnupiravir from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r2 > 0.9999) between 10 % to 50 % w/v of 100 mg of drug substance weight. The percentage recovery of molnupiravir in the optimized method was between 99.05 to 99.81 %. The method is also found to be rugged when checked by different analysts and using different lots of reagents and different makes of titrators.

Keywords


Molnupiravir, Perchloric acid, Potassium hydrogen phthalate, Glacial acetic acid.

References