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A Review of Analytical Methods for the Estimation of Ivabradine and Metoprolol in Pharmaceutical Formulations and Biological Matrices


Affiliations
1 Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, 522213, Andhra Pradesh, India., India
2 Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, 522213, Andhra Pradesh, India ., India
     

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The combination of Ivabradine (IVA) and Metoprolol (MET) was approved by US-FDA for symptomatic treatment of chronic stable angina pectoris. This Review focuses on recent development in analytical methods for IVA and MET. This review article represents the collection and discussion of various analytical methods available in the literature for the determination of IVA and MET individually and combination available in pharmaceutical and biological samples consisting of HPLC, HPTLC, GC, Thermal methods like TGA, DTA, DSC, and hyphenated techniques such as LC-MS, LC-MS/MS, and UPLC-MS/MS. All reported methods found to be simple, accurate, economic, precise and reproducible in nature. The present review article can be effectively explored to conduct future analytical investigation for the estimation of Ivabradine and Metoprolol.

Keywords

: Angina pectoris, Ivabradine, Metoprolol, Analytical Methods, RP-HPLC, LC-MS/MS.
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  • A Review of Analytical Methods for the Estimation of Ivabradine and Metoprolol in Pharmaceutical Formulations and Biological Matrices

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Authors

M. M. Eswarudu
Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, 522213, Andhra Pradesh, India., India
B. Vinay Kumar
Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, 522213, Andhra Pradesh, India., India
P. Srinivasa Babu
Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, 522213, Andhra Pradesh, India ., India

Abstract


The combination of Ivabradine (IVA) and Metoprolol (MET) was approved by US-FDA for symptomatic treatment of chronic stable angina pectoris. This Review focuses on recent development in analytical methods for IVA and MET. This review article represents the collection and discussion of various analytical methods available in the literature for the determination of IVA and MET individually and combination available in pharmaceutical and biological samples consisting of HPLC, HPTLC, GC, Thermal methods like TGA, DTA, DSC, and hyphenated techniques such as LC-MS, LC-MS/MS, and UPLC-MS/MS. All reported methods found to be simple, accurate, economic, precise and reproducible in nature. The present review article can be effectively explored to conduct future analytical investigation for the estimation of Ivabradine and Metoprolol.

Keywords


: Angina pectoris, Ivabradine, Metoprolol, Analytical Methods, RP-HPLC, LC-MS/MS.

References