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Spectrophotometric Estimation of Ofloxacin in Pharmaceutical Dosage Form
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Simple, accurate and rapid Spectrophotometric method was developed for the estimation of ofloxacin in tablet dosage form. The method is based on the absorption of electromagnetic radiation by cefixime at the maximum wavelength at 294 nm in 0.1M Hydrochloric acid as solvent. Beer's law was obeyed in the concentration range of 10-80 μg/ml. The percentage assay for commercial formulation was found to be 100.02± 0.82.Recovery value was found to be 99.95±0.54.
Keywords
Ofloxacin, Spectrophotometric Methods, Statistical Analysis, Recovery Studies
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- Indian pharmacopeia, Volume III , Govt of India, Ministry of Health and Family Welfare, Published by the controller of publication, New Delhi. 2007, 146
- Senthilraja. M . Simultaneous UV spectrophotometric method for estimation of nitazoxanide and ofloxacin in combined dosage form. Ind. J. Pharm. Tech. 2008; 1:469-471.
- Wankhede, S.B., Prakash A., Chitlange S.S. Simultaneous spectrophotometric method for estimation of ofloxacin and satranidazole in tablet dosage from” Asian J. Research Chem. 2008;1:9-11
- Fegade, D., Mehta H. P., Chaudhari, R. Y., Patil V. R. Simultaneous spectrophotometric method for estimation of ofloxacin and ketorolac tromethamine in ophthalmic dosage forms. Int. J. Chem Tech Research. 2009; 1:189-194.
- Mathur SC., Kumar Y., Murgesan N., Rathode YK.S, Sethi PD. Spectrophotometric determination of ofloxacin in pharmaceutical formulation. Indian Drugs. 1992; 29: 376-377.
- Amini M,, Abdi K., Darabi M., Shafiee A. Determination of ofloxacin in plasma by HPLC with UV Detection. J. Appli, Sci. 2005; 5: 1655-1657
- Chandhra I., Hemanth Kumar AK. Simple and rapid High performance liquid chromatography methods for the determination of ofloxacin concentration in plasma and urine. J. Chromatogar. B 2001; 760: 91 -95
- Shinde S. R., Bhor S I., Pawar N. S.,Yadav S. B., Bhagawath A.M. . Simultaneous estimation of satranidazole and ofloxacin in tablet dosage form by high performance liquid chromatography. Journal of Chemistry. 2010; 7:198-202.
- Garcia MA, Solan C, Calvo A, Royo M, Hernandej C, Rey R, Bregante MA. Analysis of ofloxacin in plasma samples by high performance liquid chromatography. Chromatographia. 2002; 55; (7-8): 431-434.
- Dhandapani B, Thirumoorthi N, Rasheed SH, Kotaiah MH, Anjaneyalu N. Method development and validation for the simultaneous estimation of ofloxacin and orinidazole in tablet dosage form by RP-HPLC. International Journal on Pharmaceutical on Biomedical Research. 2010; 1(1):42-47.
- Gandhimathi M., Ravi T. K., Shukla N. Validated high performance thin layer chromatography method for simultaneous estimation of ofloxacin and ornidazole in tablet dosage form. Ind. J. Pharm. Sci. 2006; 68:838-840.
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