Asian Journal of Research in Chemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Syntheses of Some Novel 1,3,4-Oxadiazole Derivatives and their Potential Biological Activity


Affiliations
1 Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001
     

   Subscribe/Renew Journal


A new Mannich base of quinazolin-4-one derivatives possessing 1,3,4-oxadiazole ring have been synthesized by reacting 3-[4-(5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-one (4) with different secondary amines and formaldehyde using N,N-dimethylformamide as the solvent to afford 3-[4-(4-substituted amino- 4-ylmethyl-5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-ones (5a-e). The structures of the newly synthesized compounds have been established by analytical and spectral methods. The compounds have also been screened for their biological activity.

Keywords

Synthesis, Oxadiazole, Antibacterial And Antifungal Activity
Subscription Login to verify subscription
User
Notifications
Font Size


  • J. C. Sheehan and G. D. Daves, J. Org. Chem., 29; 1964: 3599.

  • H. Heringer, Angew Chem., 76; 1964: 437.

  • M. S. Amine, A. M. F. Eissa, A. F. Shaaban, A. B. Sawy and R. El-sayed, Indian J. Heterocylic Chem., 7; 1998: 169.

  • W. L. F. Armarego, Adv. Heterocyclic Chem., 7; 1998: 1

  • Ch. Ravi Shankar, and V. Malla Reddy, J. Indian Chemical Soc., 60; 1983: 63.

  • P. F. Xu, H. Z. Hui, Z. Y. Zhang and R. L. Zheng, J. Chin. Chem. Soc., 51; 2004: 315.

  • V. J. Ram and A. J. Vlietinck, Heterocycl. Chem., 25; 1988: 253.

  • D. H. Boschelli, and C. D. Wright, J. Med. Chem., 36; 1993: 1802.

  • S. Bahadur and K. K. Pandey, J. Indian Chemical Soc., 57; 1980: 447.

  • G. Sahin, E. Palaska, M. Ekizoglu and M. Ozalp, IL Farmaco, 57; 2002: 539.

  • S. S. Tiwari and V. K. Pandey, J. Indian Chemical Soc., 52; 1975: 736.

  • Y. D. Kulkarni and S, H. Abdi, J. Indian Chemical Soc., 60; 1983: 504.

  • C. H. Collins and P. M. Lyne “Microbiological Methods” 3rd ed., Butterworths, London, 1970; pp. 424.

  • H. W. Seeley and P. J. Van Denmark, “Microbes in Action”, W.H. Freeman and Co. USA, 1972.


Abstract Views: 350

PDF Views: 2




  • Syntheses of Some Novel 1,3,4-Oxadiazole Derivatives and their Potential Biological Activity

Abstract Views: 350  |  PDF Views: 2

Authors

Freddy H. Havaldar
Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001
Azadkumar S. Sharma
Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier’s College, Mumbai - 400 001

Abstract


A new Mannich base of quinazolin-4-one derivatives possessing 1,3,4-oxadiazole ring have been synthesized by reacting 3-[4-(5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-one (4) with different secondary amines and formaldehyde using N,N-dimethylformamide as the solvent to afford 3-[4-(4-substituted amino- 4-ylmethyl-5-thioxo-4,5-dihydro-[1,3,4]oxadiazole-2-yl)-phenyl]-2-phenyl-3H-quinazolin-4-ones (5a-e). The structures of the newly synthesized compounds have been established by analytical and spectral methods. The compounds have also been screened for their biological activity.

Keywords


Synthesis, Oxadiazole, Antibacterial And Antifungal Activity

References