Asian Journal of Research in Chemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Exploring Potential of 1,5-Benzothiazepines: A Brief Review


Affiliations
1 Department of Pharmaceutical Chemistry, Y.B. Chavan College of Pharmacy. Dr. Rafiq Zakaria Campus, Aurangabad. 431001.(MS), India
     

   Subscribe/Renew Journal


Benzothiazepines are fused heterocyclic compounds. They are claimed of various therapeutic activities and hence, they are utilized in drug research. Recently, attention is being directed to their synthetic methods, chemical and biological properties. Benzothiazepines posses wide variety of biological activities like anticonvulsant, CNS depressant, Ca++ channel blockers, calcium channel modulator, calcium channel antagonist, anticancer, anti fungal antimicrobial, anti‐HIV and anti-anginal.

Keywords

1,5-benzothiazepine, CNS, Green Synthesis, Microwave –assisted
Subscription Login to verify subscription
User
Notifications
Font Size


  • Hideg, K. and Hankovszky O., Acta chim., Acad Sci, Hung, 1968; 56: 405.

  • Kugita, H., Chem. Pharm. Bull., Res., 1970; 18(10):2028-2037.

  • Krapcho, J. and Turk CF., J. Med. Chem., 1973;16:776-779.

  • Hideg, K. and Hankovszky O., Acta Chim. Acad Sci. Hung., 1971; 68: 403.

  • Levai, A. and Bognar R., Acta. Chim. Acad. Sci. Hung., 1977; 92: 415.

  • Stephens, W. and Field L., J. Org. Chem., 1959; 24: 1576–1576.

  • Murata, S., Date T., Yamaguchi T., Inoue H. and Tanaka T., Chem Pharm Bull, 1992; 40:1476-80

  • Sharma, A K., Singh G., Yadav AK. and Prakash L. Molecules, 1997; 2: 129-134.

  • Pant U C., Pant S. and Singhal B., Molecules, 1998; 3: 159-163.

  • Grandolini, G., Perioli L. and Ambrogi V., Eur. J. Med. Chem., 1999; 34(9):701-709.

  • Yuan, LI. and Yuan J., Chinese Chem. Lett., 1999; 10: 23-26. 12) Ali A., Ahmad VU., Leistner J. and Liebscher J., J. Chem. Soc., Perkin Trans. 2000; 1:1897-1902.

  • Micheli, F., Degiorgis F., Feriani A., Paio A., Pozzan A., Zarantonello P. and Seneci P., J. Comb. Chem., 2001; 3(2): 224– 228

  • Nikalje, AG., Ingle RD.,. Bhingolikar VE and Mane RA., Ind. J. Het.Chem, 2003;13: 37-40.

  • Mistry, KM. and Desai KR., Saudi Chem. Soc., 2005; 9: 381- 386.

  • Nikalje, AG., Mane RA. and Ingle DB., Ind. J. Het. Chem., 2006;15(3):309-310.

  • Nikalje, AG. Mane RA. and Ingle DB, Int. J. Chem. Sci. 2006; 4(1): 145-150.

  • Nikalje, AP., Pattan S, Int. J. Chem. Sci., 2007; 5(1): 290-296.

  • Gan, J. and Ma D., China Org. Lett., 2009; 11 (13): 2788–2790.

  • Levai, A. and Kiss-Szikszai A., Rev. Acc., 2008; 65-86.

  • Arya, K. and Dandia A., Bio. Med. Chem. Lett., 2008; 18: 114- 119.

  • Cherkupally, SR., Gurrala PR., Adki N. and Avula S., Org. Comm., 2008; 1(4) : 84-94

  • Raval, JP., Desai JT., Desai CK. and Desai K.R., ARKIVOC 2008; xii: 233-244.

  • Nikalje AG, Vyawahare, D., and Ghodke M., IJPPS, 2010; 2 (2): 27-29.

  • Nikalje, AG. and Vyawahare D., A. J. P. Applied Chem. 2011; 5(12): 422-428.


Abstract Views: 368

PDF Views: 3




  • Exploring Potential of 1,5-Benzothiazepines: A Brief Review

Abstract Views: 368  |  PDF Views: 3

Authors

A. P. G Nikalje
Department of Pharmaceutical Chemistry, Y.B. Chavan College of Pharmacy. Dr. Rafiq Zakaria Campus, Aurangabad. 431001.(MS), India
M. Ghodke
Department of Pharmaceutical Chemistry, Y.B. Chavan College of Pharmacy. Dr. Rafiq Zakaria Campus, Aurangabad. 431001.(MS), India
S. Tiwari
Department of Pharmaceutical Chemistry, Y.B. Chavan College of Pharmacy. Dr. Rafiq Zakaria Campus, Aurangabad. 431001.(MS), India

Abstract


Benzothiazepines are fused heterocyclic compounds. They are claimed of various therapeutic activities and hence, they are utilized in drug research. Recently, attention is being directed to their synthetic methods, chemical and biological properties. Benzothiazepines posses wide variety of biological activities like anticonvulsant, CNS depressant, Ca++ channel blockers, calcium channel modulator, calcium channel antagonist, anticancer, anti fungal antimicrobial, anti‐HIV and anti-anginal.

Keywords


1,5-benzothiazepine, CNS, Green Synthesis, Microwave –assisted

References