Asian Journal of Research in Chemistry

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A Novel Efficient Synthetic Strategy for (±)Carvedilol, an Antihypertensive Drug


Affiliations
1 Department of Chemistry, JNT University, Anantapuram, Andhra Pradesh, India
2 Department of Chemistry, KL University, Vaddeswaram ,Guntur - 522502, A.P, India
3 Department of Chemistry, Krishna University, Machilipatnam - 521 001, India
     

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A New and alternate simple synthetic strategy of carvedilol, -adrenergic blocking agent and its analogs, The key step in this approach is synthesis of 3-(9H-carbazol-4-yloxy)-2-hydroxypropyl 4-methylbenzenesulfonate, it is wished to report towards synthesis of Carvedilol this approach is more efficient , improved overall yield, easy process and to avoid the process impurities.

Keywords

β,-adrenergic Blocking Agents, Antihypertensive Efficacy Drug Suzuki Coupling, Regioselective Tosylation, Cyclisation, Yields
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  • A Novel Efficient Synthetic Strategy for (±)Carvedilol, an Antihypertensive Drug

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Authors

M Yedukondalu
Department of Chemistry, JNT University, Anantapuram, Andhra Pradesh, India
R Sridhar
Department of Chemistry, KL University, Vaddeswaram ,Guntur - 522502, A.P, India
M.V Basaveswara Rao
Department of Chemistry, Krishna University, Machilipatnam - 521 001, India

Abstract


A New and alternate simple synthetic strategy of carvedilol, -adrenergic blocking agent and its analogs, The key step in this approach is synthesis of 3-(9H-carbazol-4-yloxy)-2-hydroxypropyl 4-methylbenzenesulfonate, it is wished to report towards synthesis of Carvedilol this approach is more efficient , improved overall yield, easy process and to avoid the process impurities.

Keywords


β,-adrenergic Blocking Agents, Antihypertensive Efficacy Drug Suzuki Coupling, Regioselective Tosylation, Cyclisation, Yields

References