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Simultaneous Quantification of Salbutamol and Theophylline by Validated Spectrophotometric Method in Tablet Dosage form
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In the present study, spectrophotometric method was developed and validated using multicomponent mode for simultaneous estimation of Salbutamol Sulphate and Theophylline in combined tablet dosage form. Distilled water was used as a solvent. Considering the absorption of both the analytes in the range of 200 nm - 320 nm, four wavelength of equal interval of 40 nm were selected such as 320 nm, 280 nm, 240 nm and 200 nm for analysis of these drugs. The mean percentage assay was found as 100.50% and 100.79% for Salbutamol Sulphate and Theophylline respectively. Results of analysis were validated statistically in accordance with ICH guidelines for accuracy and precision of the method. The results of recovery study were observed in the range of 93.26-99.24%. for Salbutamol Sulphate and 97.39-103.615% for Theophylline, While, the % RSD for precision study was observed less than 1 %. So, it can be concluded that, the developed method is simple, accurate, economical and easy to apply, making it suitable for routine analysis of Salbutamol Sulphate and Theophylline in tablet dosage form.
Keywords
Salbutamol Sulphate, Theophylline, Multicomponent Spectroscopy
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- en.wikipedia.org/wiki/Asthma#cite_note_lemanske-9 (access date Dec 6,2011)
- www.drugbank.ca/drugs/DB01001 (access date Dec 6, 2011).
- www.drugbank.ca/drugs/DB00277 (access date Dec 6, 2011).
- www.ncbi.nlm.nih.gov/pubmed/90618 (access date Nov 16, 2011)
- Maithani M, Singh R. Development and validation of a stabilityindicating HPLC method for the simultaneous determination of Salbutamol Sulphate and Theophylline in pharmaceutical dosage forms. Journal of Analytical and Bioanalytical Techniques.2011; 1:116
- Chitlange SS, Chaturvedi KK, Wankhede SB. Development and validation of spectrophotometric and HPLC Method for the simultaneous estimation of Salbutamol Sulphate and Prednisolone in tablet dosage form. Journal of Analytical and Bioanalytical Techniques.2011;2:117.
- Shidhaye S, Malke S, Kadam V. Validated stability indicating HPLC method for estimation of Theophylline from a novel microsphere formulation. Asian Journal of Pharmaceutics.2009;3(1):13-7
- Chen C, Li H, Fan Y, Detemination of Salbutamol Sulphate in medicaments by capillary electrophoresis with contactless conductivity detection. China Journal of Chromatography/ SE PU. 2011;28(2):137-40
- Patel PA, Dole MN, Shedpure PS, Sawant SD. Spectrophotometric simultaneous estimation of Salbutamol and Ambroxol in bulk and formulation. Asian Journal of Pharmaceutical and Clinical Reserch.2011; 4(3):42-5.
- Mishra AK, Kumar M, Mishra A, Verma A, Chattopadhyay P. Validated UV spectroscopic method for estimation of Salbutamol from tablet formulations. Archive of Apllied Science Reserch.2010;2(3):207-11.
- Kanakapura B, Bankavadi C.S, Veeraiah R, Rapid Titrimetric and spectrophotometric method for Salbutamol Sulphate in pharmaceutical using N-Bromosuccimide. Acta Pharmaceutica.2007:57(1); 87-98
- Basavaiah K, Prameela H.C., Bromimetric methods for the determination of Salbutamol Sulphate. Analytical and Bioanalytical Chemistry, July2003: 376(6); 879
- Niyazi Y, Sibel A, Ozakan, Bengi U, Zuhre S, Inci B, Voltammetric determination of Salbutamol based on electrochemical oxidation at platinum and glassay carbon electrodes. Turkish Journal of Chemistry.1998:22,175-182
- ICH Guidance on Analytical Method Validation, in: Proceedings of the International Convention on Quality for the Pharmaceutical Industry, Toronto, Canada, and September, 2002.
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