Asian Journal of Research in Chemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Spectrophotometric and FIA methods for determination of Loratadine in pharmaceutical formulations based on charge transfer reaction


Affiliations
1 Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
     

   Subscribe/Renew Journal


A rapid and sensitive Spectrophotometric and FIA method are described for the determination of Loratadine drug in both pure and dosage forms. The determination was based on the formation of charge transfer complexes between metol (N-methyl-p-hydroxy aniline) as - acceptor and the studied drugs as n-donors in acetonitrile a polar aprotic solvent.

The colored product is measured at max 540 nm . Under the optimum conditions calibration graph was observed a linear from 10-50 μg ml-1 LOR and with correlation coefficient not less than 0.9991which was suitable for the quantitative determination of the drug.The molar absorbitivity was 2.431 × 104L.mole-1.cm-1,and sandell sensitivity of 0.01162µg cm-2 .The relative standard deviation of the proposed method was 0. 5-2.4% depending on the concentration of LOR. The proposed method was successfully applied to the determination of LOR in tablets and syrups.


Keywords

Loratadine, Metol, Charge Transfer Complexes
Subscription Login to verify subscription
User
Notifications
Font Size


  • M.Z. Khan, D. Rausl, R. Zanoski, S. Zidar, J.H. Mikulci´ c, L. Krizmani´ c, M. Eskinja, B. Mildner, Z. Knezevi´ c, Classification of loratadine based on the biopharmaceutics drug classification concept and possible in vitro–in vivo correlation, Biol.Pharm. Bull. 27 (2004) 1630–1635.

  • Lourance DR,Benett PN and Brown MJ . Histamine antihistamines and allergies .In Clinical pharmacology, ninth ed.2003:p 553-556)

  • Shamsi Z,Kimber S,Hindmarch I.An investigation into the effects of cetrizine oncognitive functions and psychomotor performance in healthy volunteers.Eur. J.Pharmacol. 2001;56(12):865-71.

  • Hindmarch JS,Meadows.The acute and subchronic effects of levocetrizine,loratadine,, cetrizine, promethazine and placebo on cognitive function ,psychomotorperformance and wheal and flare.Curr.Med.Res.Opin.2001;17(4):241-55.

  • Hindmarch JS, Shamsi Z.The effects of single and repeated administration of ebastine on cognitive and psychomotor performance in comparison to tripolidine and placebo in healthy volunteers.Ccurr.Med.Res.Opin.2001;17(4):274-81).

  • G. Popovic, M. Cakar, and D. Agbaba Simultaneous determination of Loratadine and preservatives in syrups by thinlayer Chromatography(Acta Chromatographic, No. 19, 2007 Serbia ).

  • F.J. Rupe´rez, H. Ferna´ndez, C. Barbas.Determination of loratadine and related impurities .Journal of Pharmaceutical and Biomedical Analysis .29 (2002) 35–41 LC, Spain .

  • A.D. de Jager, D. Badenhorst, T. Scanes, H.K.L. Hundt, K.J. Swart, A.F. Hundt. Sensitive liquid chromatography–tandem mass spectrometry method for the determination of loratadine and its major active metabolite descarboethoxyloratadine in human plasma. Journal of Chromatography A, 914 (2001) 37–43 F.C.W. Sutherland, , South Africa.

  • Jianguo Sun ,Guangji Wang ,Wei Wang, Shuai Zhao, Yi Gu, Jinwen Zhang, Mingwen Huang, Fen Shao, Hao Li, Qi Zhang. Haitang Xie Journal of Pharmaceutical and Biomedical Analysis 2005, Pages 217–224 . China .

  • Culzoni MJ, Goicoechea HC. Anal Bioanal Chem. 2007 Dec;389(7-8):2217-25. Epub 2007, Argentina.

  • H. Ferna´ndez, F.J. Rupe´rez, C. Barbas , Spain Journal of Pharmaceutical and Biomedical Analysis 31 (2003) 499/506).


Abstract Views: 272

PDF Views: 2




  • Spectrophotometric and FIA methods for determination of Loratadine in pharmaceutical formulations based on charge transfer reaction

Abstract Views: 272  |  PDF Views: 2

Authors

Bushra B. Qassim
Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq

Abstract


A rapid and sensitive Spectrophotometric and FIA method are described for the determination of Loratadine drug in both pure and dosage forms. The determination was based on the formation of charge transfer complexes between metol (N-methyl-p-hydroxy aniline) as - acceptor and the studied drugs as n-donors in acetonitrile a polar aprotic solvent.

The colored product is measured at max 540 nm . Under the optimum conditions calibration graph was observed a linear from 10-50 μg ml-1 LOR and with correlation coefficient not less than 0.9991which was suitable for the quantitative determination of the drug.The molar absorbitivity was 2.431 × 104L.mole-1.cm-1,and sandell sensitivity of 0.01162µg cm-2 .The relative standard deviation of the proposed method was 0. 5-2.4% depending on the concentration of LOR. The proposed method was successfully applied to the determination of LOR in tablets and syrups.


Keywords


Loratadine, Metol, Charge Transfer Complexes

References